NANOSTRUCTURED SYSTEMS BASED ON GLUCOMANNAN DERIVED FROM ALOE VERA AS AN ALTERNATIVE IN THE TREATMENT OF WOUND HEALING: INTEGRATIVE LITERATURE REVIEW

Abstract

The wound healing process is a complex and dynamic event that is triggered by the existence of an injured tissue. Chronic skin lesions, especially those that affect patients with comorbidities, are one of the greatest examples of the stagnation phase of inflammation and that lead to healing problems. One of the most modern and recent alternatives in the field of tissue engineering that aims to propose new alternatives for the treatment of wound healing is nanotechnology. Thus, this study aimed to carry out an integrative literature review in order to relate the most recent and relevant studies on the latest innovations in the field of wound healing treatment that make use of nanostructured systems based on actives derived from Aloe vera . For this, searches were carried out in the Science Direct and Pubmed databases to search for articles related to the proposed theme. The final sample consisted of 12 scientific articles, according to previously established criteria. Several experimental studies involving nanostructured models in association with Aloe vera and other actives were analyzed, where they presented positive results regarding the possibility of application. Thus, it was concluded that despite the positive results obtained, it is still necessary to carry out new controlled clinical studies to support and prove the real effectiveness of these dressings.