Abstract
The objective of this study is to systematically analyze recent scientific literature on the neurobiological and psychological mechanisms underlying anticipatory anxiety in adolescents, as well as to evaluate the effectiveness of brief psychotherapeutic interventions and emotional self-regulation techniques, following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The method adopted was a systematic literature review of the last five years (2021–2026), covering epidemiological and neurobiological studies and clinical trials on interventions such as cognitive-behavioral therapy (CBT), acceptance and commitment therapy (ACT), and mindfulness practices, identified in PubMed, PsycINFO, Web of Science, and Scopus databases. After applying eligibility criteria, 20 studies were included in the qualitative synthesis. The results demonstrate that anticipatory anxiety in adolescents shows an increasing prevalence — exceeding 20% in American populations in 2023 — negatively impacting social and academic functioning, associated with asymmetric maturation of the prefrontal cortex and amygdala hyperactivity. Mindfulness-based interventions and cognitive reappraisal show significant effectiveness in reducing symptoms, promoting greater psychological flexibility. Digital CBT-based interventions show moderate effect sizes and constitute an accessible alternative to in-person treatment. The main conclusion indicates that brief intervention protocols integrating rapid emotional regulation techniques — such as diaphragmatic breathing and self-compassion — are crucial to mitigate anticipatory anxiety effects, providing essential support for the development of digital tools and school-based interventions. Limitations include methodological heterogeneity among included studies and the scarcity of randomized clinical trials with representative samples from low- and middle-income countries.
References
CSIRMAZ, L.; NAGY, T.; VIKOR, F.; KASOS, K. Cognitive Behavioral Digital Interventions are Effective in Reducing Anxiety in Children and Adolescents: A Systematic Review and Meta-analysis. Journal of Primary Prevention, v. 45, n. 1, p. 1-22, 2024. https://doi.org/10.1007/s10935-023-00760-0
CZUB, M.; KOWAL, M.; ZARAZAGA, R. E.; SERRANO-IBÁÑEZ, E. R.; RUÍZ-PÁRRAGA, G. T. et al. A slow diaphragmatic breathing intervention for anxiety: How do respiration rate and inhalation/exhalation ratio influence self-reported anxiety? Stress & Health, v. 40, n. 6, e3496, 2024. https://doi.org/10.1002/smi.3496
GOODPASTER, C. M.; CHRISTENSEN, C. R.; ALTURKI, M.; DENARDO, L. A. Prefrontal cortex development and its implications in mental illness. Neuropsychopharmacology, 2025. https://doi.org/10.1038/s41386-025-02154-8
HUE, V. C.; SIAW, Y. L.; NOR, A. M. A systematic review of mindfulness-based stress reduction in the management of anxiety disorders among adolescents and young adults aged 13-26. Asian Journal of Psychiatry, v. 108, p. 104497, 2025. https://doi.org/10.1016/j.ajp.2025.104497
HUDSON, J. L.; MCLELLAN, L. F.; EAPEN, V.; RAPEE, R. M.; WUTHRICH, V.; LYNEHAM, H. J. Combining CBT and sertraline does not enhance outcomes for anxious youth: a double-blind randomised controlled trial. Psychological Medicine, v. 53, n. 5, p. 1741-1749, 2023. https://doi.org/10.1017/S0033291721003329
JI, H.-G.; KANG, S.; BAE, H.; KIM, G.; HUR, J.-W. Efficacy of Digital Interventions for Anxiety Disorders: A Systematic Review and Meta-Analysis. European Psychiatry, 2024. https://doi.org/10.1192/j.eurpsy.2024.774
KAMARUDZAMAN, W.; SULAIMAN, S.; JANON, N. S.; AHMAD, Z.; ISMAIL, N. A. H.; KARIM, A. H. A. Association Between Anticipatory Thinking and Adolescent Depression, Anxiety and Stress. Malaysian Journal of Social Sciences and Humanities (MJSSH), v. 11, n. 1, e003741, 2026. https://doi.org/10.47405/mjssh.v11i1.3741
KENWOOD, M. M.; KALIN, N. H.; BARBAS, H. The prefrontal cortex, pathological anxiety, and anxiety disorders. Neuropsychopharmacology, v. 47, n. 1, p. 260-275, 2022. https://doi.org/10.1038/s41386-021-01109-z
MURIS, P.; FERNÁNDEZ-MARTÍNEZ, I.; OTGAAR, H. On the Edge of Psychopathology: Strong Relations Between Reversed Self-compassion and Symptoms of Anxiety and Depression in Young People. Clinical Child and Family Psychology Review, v. 27, n. 2, p. 407-423, 2024. https://doi.org/10.1007/s10567-024-00471-w
NGUYEN, A.; GRUMMITT, L.; BARRETT, E. L.; BAILEY, S.; GARDNER, L. A.; CHAMPION, K. E. et al. The relationship between emotion regulation and mental health in adolescents: Self-compassion as a moderator. Mental Health & Prevention, v. 38, p. 200430, 2025. https://doi.org/10.1016/j.mhp.2025.200430
OHI, K. Clinical features and genetic mechanisms of anxiety, fear. Molecular Psychiatry, 2025. https://doi.org/10.1038/s41380-025-03155-1
PETERSEN, J. M.; PIMENTEL, S. S. Acceptance and Commitment Therapy for Adolescent Anxiety. Current Treatment Options in Psychiatry, v. 11, p. 366-372, 2024. https://doi.org/10.1007/s40501-024-00335-8
RACINE, N.; MCARTHUR, B. A.; COOKE, J. E.; EIRICH, R.; ZHU, J.; MADIGAN, S. Global Prevalence of Depressive and Anxiety Symptoms in Children and Adolescents During COVID-19: A Meta-analysis. JAMA Pediatrics, v. 175, n. 11, p. 1142-1150, 2021. https://doi.org/10.1001/jamapediatrics.2021.2482
REYNARD, S.; DIAS, J.; MITIC, M.; SCHRANK, B.; WOODCOCK, K. A. Digital Interventions for Emotion Regulation in Children and Early Adolescents: Systematic Review and Meta-analysis. JMIR Serious Games, v. 10, n. 3, e31456, 2022. https://doi.org/10.2196/31456
ROMEO, R. D. The Teenage Brain: The Stress Response and the Adolescent Brain. Current Directions in Psychological Science, v. 22, n. 2, p. 140-145, 2013. https://doi.org/10.1177/0963721413475445
SAPPENFIELD, O.; ALBERTO, C.; MINNAERT, J.; DONNEY, J.; LEBRUN-HARRIS, L.; GHANDOUR, R. Adolescent Mental and Behavioral Health, 2023. National Survey of Children’s Health Data Briefs, 2024. Available at: https://www.ncbi.nlm.nih.gov/books/NBK608531/
TALI, E.; POTHARST, E. S.; DE BRUIN, E. I.; UTENS, E. M. W. J. Self-Compassion and Anxiety in Adolescents with and without Anxiety Disorder. Children, v. 10, n. 7, p. 1181, 2023. https://doi.org/10.3390/children10071181
VISWANATHAN, M.; MIDDLETON, J. C.; STUEBE, A. M.; BERKMAN, N.; GODINO, J. G. et al. Screening for Anxiety in Children and Adolescents: Evidence Report and Systematic Review for the US Preventive Services Task Force. JAMA, v. 328, n. 14, p. 1445-1455, 2022. https://doi.org/10.1001/jama.2022.16303
WALDER, N.; FREY, A.; BERGER, T.; SCHMIDT, S. J. Digital Mental Health Interventions for the Prevention and Treatment of Social Anxiety Disorder in Children, Adolescents, and Young Adults: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Medical Internet Research, 2025. https://doi.org/10.2196/67067
WICKERSHAM, A.; BARACK, T.; CROSS, L.; DOWNS, J. Computerized Cognitive Behavioral Therapy for Treatment of Depression and Anxiety in Adolescents: Systematic Review and Meta-analysis. Journal of Medical Internet Research, v. 24, n. 4, e29842, 2022. https://doi.org/10.2196/29842
WRIGHT, M.; REITEGGER, F.; CELA, H.; PAPST, A.; GASTEIGER-KLICPERA, B. Interventions with Digital Tools for Mental Health Promotion among 11-18 Year Olds: A Systematic Review and Meta-Analysis. Journal of Youth and Adolescence, v. 52, n. 4, p. 754-779, 2023. https://doi.org/10.1007/s10964-023-01735-4

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