Palavras-chave
Aloe vera
Glucomanano
Cicatrização
Nanotecnologia
Ciclodextrinas
Glucomanano
Cicatrização
Nanotecnologia
Ciclodextrinas
Como Citar
Fortes, C., & Ferreira de Barros Leite, N. . (2021). COMPLEXOS DE INCLUSÃO DE CICLODEXTRINAS E GLUCOMANANO DERIVADO DA ALOE VERA NO DESENVOLVIMENTO DE FORMULAÇÕES COM AÇÃO CICATRIZANTE. Estudos Avançados Sobre Saúde E Natureza, 1. Recuperado de https://periodicojs.com.br/index.php/easn/article/view/301
Resumo
Os diversos inconvenientes causados por lesões, em especial as feridas crônicas, representam uma das limitações da medicina atualmente. Dessa forma, no âmbito das alternativas para a reparação de danos teciduais, diversas espécies vegetais são amplamente estudadas como forma de propor novas terapêuticas para o tratamento de feridas, e dentre a espécies estudadas a Aloe vera sempre é um destaque. Ao se observar essas intercorrências, esforços significativos são feitos com o objetivo de buscar novos tratamentos e aprimoramentos dessas terapias. Umas das alternativas mais promissora que se tornou o foco de estudo nesta área são os sistemas de entrega baseados em nanotecnologia para a liberação de drogas e ativos de forma local e controlada. Diante disto, o presente estudo teve como objetivo realizar um levantamento bibliográfico a fim de correlacionar a possibilidade de aplicação do Glucomanano derivado da Aloe vera, complexado a ciclodextrinas, como um sistema de entrega para utilização em terapias de cicatrização de feridas. Utilizou-se as bases de dados Science Direct e Pubmed para fazer o levantamento dos estudos envolvendo a temática escolhida. Foram incluídos os artigos que abordavam diretamente sobre a temática estabelecida, envolvendo estudos experimentais e clínicos sobre as aplicações da A. vera e glucomanano em um sistema nanoestruturados para aplicações em terapias de reparação de danos teciduais. A partir do levantamento bibliográfico feito nas bases de dados, foram escolhidos um total 30 artigos para leitura completa, e ao final 25 estudos foram escolhidos para compor esta pesquisa. Os números de estudos encontrados ao todo a partir das buscas com os descritores escolhidos foi bastante expressiva, apresentando uma quantidade significativa de resultados. A partir deste estudo, pode-se afirmar que a continuidade da pesquisa envolvendo a utilização do glucomanano complexado a ciclodextrinas é favorável o que implica em bons resultados.
Referências
ALDAG, Caroline; TEIXEIRA, Diana Nogueira; LEVENTHAL, Phillip s. Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a review of the literature. Clinical, Cosmetic And Investigational Dermatology, v. 9, n. 9, p. 411-419, 2016.
ALVES, Natália Cristina. Penetração de ativos na pele: revisão bibliográfica. Amazônia: science & health, v. 3, n. 4, p. 36 a 43-36 a 43, 2015.
BERNARDO, A. F. C.; SANTOS, K.; SILVA, D. P. Pele: alterações anatômicas e fisiológicas do nascimento à maturidade. Revista Saúde em Foco, v. 1, n. 11, p. 1221-33, 2019.
BRASILEIRO FILHO, G. Bogliolo - Patologia. 9. ed. Rio de Janeiro: Gen, Guanabara Koogan, 2016.
CARNEIRO, Simone Braga et al. Cyclodextrin–drug inclusion complexes: In vivo and in vitro approaches. International journal of molecular sciences, v. 20, n. 3, p. 642, 2019.
CHEN, Honglei et al. A novel wound dressing based on a Konjac glucomannan/silver nanoparticle composite sponge effectively kills bacteria and accelerates wound healing. Carbohydrate polymers, v. 183, p. 70-80, 2018.
ČUŘÍKOVÁ, Barbora Amélie et al. Simplified stratum corneum model membranes for studying the effects of permeation enhancers. International journal of pharmaceutics, v. 534, n. 1-2, p. 287-296, 2017.
DEBJIT, Bhowmik et al. Aloe vera-gift to mankind. International Journal of Minor Fruits, Medicinal and Aromatic Plants, v. 5, n. 1, p. 1-6, 2019.
DOLATI, Sanam et al. Prospects for the application of growth factors in wound healing. Growth Factors, v. 38, n. 1, p. 25-34, 2020.
ESSA, Rasha; MOHAMED, N.; KANDEEL, Hanan. Effect of aloe vera gel versus normal saline on pain relief and healing process of episiotomy. JHMN, v. 70, p. 66-81, 2020.
FERREIRA, J. F. S. Nanoencapsulation of essential oils for cosmetic application. Dissertação. Universidade de Coimbra. 2019.
GARCIA-ORUE, Itxaso et al. Composite nanofibrous membranes of PLGA/Aloe vera containing lipid nanoparticles for wound dressing applications. International journal of pharmaceutics, v. 556, p. 320-329, 2019.
GARCIA-ORUE, Itxaso et al. Nanotechnology-based delivery systems to release growth factors and other endogenous molecules for chronic wound healing. Journal of Drug Delivery Science and Technology, v. 42, p. 2-17, 2017.
GIANINO, Elizabeth; MILLER, Craig; GILMORE, Jordon. Smart wound dressings for diabetic chronic wounds. Bioengineering, v. 5, n. 3, p. 51, 2018.
GIRSANG, Rezky Sagita et al. Effect of Aloe vera Extracts towards the Fibroblast Number and Collagen Thickness on Clean Skin Wound Healing on Rattus Novergicus. Systematic Reviews in Pharmacy, v. 11, n. 5, p. 571-573, 2020.
HAMDAN, Suzana et al. Nanotechnology-driven therapeutic interventions in wound healing: potential uses and applications. ACS central science, v. 3, n. 3, p. 163-175, 2017.
HAN, George; CEILLEY, Roger. Chronic wound healing: a review of current management and treatments. Advances in therapy, v. 34, n. 3, p. 599-610, 2017
HAN, Hongwei; ROAN, Florence; ZIEGLER, Steven F. The atopic march: current insights into skin barrier dysfunction and epithelial cell‐derived cytokines. Immunological reviews, v. 278, n. 1, p. 116-130, 2017.
HUSEIN EL HADMED, Husein; CASTILLO, Rafael Fernandez. Cosmeceuticals: peptides, proteins, and growth factors. Journal of cosmetic dermatology, v. 15, n. 4, p. 514-519, 2016.
ISHIHARA, Jun et al. Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing. Nature communications, v. 9, n. 1, p. 1-14, 2018.
JUNQUEIRA, L. C.; CARNEIRO, José. Histologia básica. 13.ed. Rio de Janeiro: Guanabara Koogan, 2017
KHAVKIN, Jeannie; ELLIS, David AF. Aging skin: histology, physiology, and pathology. Facial Plastic Surgery Clinics, v. 19, n. 2, p. 229-234, 2011.
KIERZENBAUM, A. L.; TRES, L. L. Histologia e biologia celular: uma introdução à patologia. 4 ed. Rio de Janeiro: Elsevier, 2012.
KIM, Hyoung Ja et al. Concise synthesis of aloesone and aloesol natural products. Bulletin of the Korean Chemical Society, v. 38, n. 10, p. 1121-1122, 2017.
KIM, Yun Seop et al. Synergistic effects of hyaluronate–epidermal growth factor conjugate patch on chronic wound healing. Biomaterials science, v. 6, n. 5, p. 1020-1030, 2018.
KUMAR, Ramesh et al. Therapeutic potential of Aloe vera—A miracle gift of nature. Phytomedicine, v. 60, p. 152996, 2019.
KUMAR, V.; ABBAS, A.; FAUSTO, N. Robbins e Cotran – Patologia – Bases Patológicas das Doenças. 8. ed. Rio de Janeiro: Elsevier, 2010.
LI, Jun-yi et al. A systematic review exploring the anticancer activity and mechanisms of glucomannan. Frontiers in pharmacology, v. 10, p. 930, 2019.
MAAN, Abid Aslam et al. The therapeutic properties and applications of Aloe vera: A review. Journal of Herbal Medicine, v. 12, p. 1-10, 2018.
MARTINELLO, T. et al. Allogeneic mesenchymal stem cells improve the wound healing process of sheep skin. BMC veterinary research, v. 14, n. 1, p. 1-9, 2018.
MOHAMMADI, Zoheyr et al. The effect of chrysin–curcumin-loaded nanofibres on the wound-healing process in male rats. Artificial cells, nanomedicine, and biotechnology, v. 47, n. 1, p. 1642-1652, 2019.
ORYAN, Ahmad et al. Healing potential of injectable Aloe vera hydrogel loaded by adipose-derived stem cell in skin tissue-engineering in a rat burn wound model. Cell and tissue research, v. 377, n. 2, p. 215-227, 2019.
PARK, Jin Woo; HWANG, Seung Rim; YOON, In-Soo. Advanced growth factor delivery systems in wound management and skin regeneration. Molecules, v. 22, n. 8, p. 1259, 2017.
PARK, Ye Ri et al. NF-κB signaling is key in the wound healing processes of silk fibroin. Acta biomaterialia, v. 67, p. 183-195, 2018.
PIRES, Felipe Q. et al. Lipid nanoparticles as carriers of cyclodextrin inclusion complexes: A promising approach for cutaneous delivery of a volatile essential oil. Colloids and Surfaces B: Biointerfaces, v. 182, p. 110382, 2019.
PUGLIA, Carmelo; SANTONOCITO, Debora. Cosmeceuticals: Nanotechnology-Based Strategies for the Delivery of Phytocompounds. Current pharmaceutical design, v. 25, n. 21, p. 2314-2322, 2019.
SHI, Xiao-Dan et al. Structural and conformational characterization of linear O-acetyl-glucomannan purified from gel of Aloe barbadensis Miller. International journal of biological macromolecules, v. 120, p. 2373-2380, 2018.
SINGH, Shailendra; YOUNG, Alistair; MCNAUGHT, Clare-Ellen. The physiology of wound healing. Surgery (Oxford), v. 35, n. 9, p. 473-477, 2017.
SOARES, Margarida; VITORINO, Carla; SOUSA, João; PAIS, Alberto. Permeação cutânea: desafios e oportunidades. Revista de Ciências Farmacêuticas Básica e Aplicada, v. 36, n. 3, p. 337-348, 2015.
TESTER, Richard; AL-GHAZZEWI, Farage H. Role of glucomannans in immunology. Journal of Pharmacy & Pharmaceutical Sciences, v. 20, p. 97-114, 2017.
TIAN, Bingren et al. The application and prospects of cyclodextrin inclusion complexes and polymers in the food industry: A review. Polymer International, v. 69, n. 7, p. 597-603, 2020.
TOTTOLI, Erika Maria et al. Skin wound healing process and new emerging technologies for skin wound care and regeneration. Pharmaceutics, v. 12, n. 8, p. 735, 2020.
YANG, S. et al. Encapsulating plant ingredients for dermocosmetic application: An updated review of delivery systems and characterization techniques. International journal of cosmetic science, v. 42, n. 1, p. 16-28, 2020.
YOKOTA, Junko; KYOTANI, Shojiro. Influence of nanoparticle size on the skin penetration, skin retention and anti-inflammatory activity of non-steroidal anti-inflammatory drugs. Journal of the Chinese Medical Association, v. 81, n. 6, p. 511-519, 2018.
ZADEH GHARABOGHAZ, Morteza Najaf; FARAHPOUR, Mohammad Reza; SAGHAIE, Shahram. Topical co-administration of Teucrium polium hydroethanolic extract and Aloe vera gel triggered wound healing by accelerating cell proliferation in diabetic mouse model. Biomedicine & Pharmacotherapy, v. 127, p. 110189, 2020.
ZAREI, Farshad; SOLEIMANINEJAD, Maryam. Role of growth factors and biomaterials in wound healing. Artificial cells, nanomedicine, and biotechnology, v. 46, n. sup1, p. 906-911, 2018.
ZARZYCKI, Paweł K. et al. Cyclodextrins-based nanocomplexes for encapsulation of bioactive compounds in food, cosmetics, and pharmaceutical products: principles of supramolecular complexes formation, their influence on the antioxidative properties of target chemicals, and recent advances in selected industrial applications. Encapsulations, p. 717-767, 2016.
ZSIKÓ, Stella et al. Methods to evaluate skin penetration in vitro. Scientia Pharmaceutica, v. 87, n. 3, p. 19, 2019.
ALVES, Natália Cristina. Penetração de ativos na pele: revisão bibliográfica. Amazônia: science & health, v. 3, n. 4, p. 36 a 43-36 a 43, 2015.
BERNARDO, A. F. C.; SANTOS, K.; SILVA, D. P. Pele: alterações anatômicas e fisiológicas do nascimento à maturidade. Revista Saúde em Foco, v. 1, n. 11, p. 1221-33, 2019.
BRASILEIRO FILHO, G. Bogliolo - Patologia. 9. ed. Rio de Janeiro: Gen, Guanabara Koogan, 2016.
CARNEIRO, Simone Braga et al. Cyclodextrin–drug inclusion complexes: In vivo and in vitro approaches. International journal of molecular sciences, v. 20, n. 3, p. 642, 2019.
CHEN, Honglei et al. A novel wound dressing based on a Konjac glucomannan/silver nanoparticle composite sponge effectively kills bacteria and accelerates wound healing. Carbohydrate polymers, v. 183, p. 70-80, 2018.
ČUŘÍKOVÁ, Barbora Amélie et al. Simplified stratum corneum model membranes for studying the effects of permeation enhancers. International journal of pharmaceutics, v. 534, n. 1-2, p. 287-296, 2017.
DEBJIT, Bhowmik et al. Aloe vera-gift to mankind. International Journal of Minor Fruits, Medicinal and Aromatic Plants, v. 5, n. 1, p. 1-6, 2019.
DOLATI, Sanam et al. Prospects for the application of growth factors in wound healing. Growth Factors, v. 38, n. 1, p. 25-34, 2020.
ESSA, Rasha; MOHAMED, N.; KANDEEL, Hanan. Effect of aloe vera gel versus normal saline on pain relief and healing process of episiotomy. JHMN, v. 70, p. 66-81, 2020.
FERREIRA, J. F. S. Nanoencapsulation of essential oils for cosmetic application. Dissertação. Universidade de Coimbra. 2019.
GARCIA-ORUE, Itxaso et al. Composite nanofibrous membranes of PLGA/Aloe vera containing lipid nanoparticles for wound dressing applications. International journal of pharmaceutics, v. 556, p. 320-329, 2019.
GARCIA-ORUE, Itxaso et al. Nanotechnology-based delivery systems to release growth factors and other endogenous molecules for chronic wound healing. Journal of Drug Delivery Science and Technology, v. 42, p. 2-17, 2017.
GIANINO, Elizabeth; MILLER, Craig; GILMORE, Jordon. Smart wound dressings for diabetic chronic wounds. Bioengineering, v. 5, n. 3, p. 51, 2018.
GIRSANG, Rezky Sagita et al. Effect of Aloe vera Extracts towards the Fibroblast Number and Collagen Thickness on Clean Skin Wound Healing on Rattus Novergicus. Systematic Reviews in Pharmacy, v. 11, n. 5, p. 571-573, 2020.
HAMDAN, Suzana et al. Nanotechnology-driven therapeutic interventions in wound healing: potential uses and applications. ACS central science, v. 3, n. 3, p. 163-175, 2017.
HAN, George; CEILLEY, Roger. Chronic wound healing: a review of current management and treatments. Advances in therapy, v. 34, n. 3, p. 599-610, 2017
HAN, Hongwei; ROAN, Florence; ZIEGLER, Steven F. The atopic march: current insights into skin barrier dysfunction and epithelial cell‐derived cytokines. Immunological reviews, v. 278, n. 1, p. 116-130, 2017.
HUSEIN EL HADMED, Husein; CASTILLO, Rafael Fernandez. Cosmeceuticals: peptides, proteins, and growth factors. Journal of cosmetic dermatology, v. 15, n. 4, p. 514-519, 2016.
ISHIHARA, Jun et al. Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing. Nature communications, v. 9, n. 1, p. 1-14, 2018.
JUNQUEIRA, L. C.; CARNEIRO, José. Histologia básica. 13.ed. Rio de Janeiro: Guanabara Koogan, 2017
KHAVKIN, Jeannie; ELLIS, David AF. Aging skin: histology, physiology, and pathology. Facial Plastic Surgery Clinics, v. 19, n. 2, p. 229-234, 2011.
KIERZENBAUM, A. L.; TRES, L. L. Histologia e biologia celular: uma introdução à patologia. 4 ed. Rio de Janeiro: Elsevier, 2012.
KIM, Hyoung Ja et al. Concise synthesis of aloesone and aloesol natural products. Bulletin of the Korean Chemical Society, v. 38, n. 10, p. 1121-1122, 2017.
KIM, Yun Seop et al. Synergistic effects of hyaluronate–epidermal growth factor conjugate patch on chronic wound healing. Biomaterials science, v. 6, n. 5, p. 1020-1030, 2018.
KUMAR, Ramesh et al. Therapeutic potential of Aloe vera—A miracle gift of nature. Phytomedicine, v. 60, p. 152996, 2019.
KUMAR, V.; ABBAS, A.; FAUSTO, N. Robbins e Cotran – Patologia – Bases Patológicas das Doenças. 8. ed. Rio de Janeiro: Elsevier, 2010.
LI, Jun-yi et al. A systematic review exploring the anticancer activity and mechanisms of glucomannan. Frontiers in pharmacology, v. 10, p. 930, 2019.
MAAN, Abid Aslam et al. The therapeutic properties and applications of Aloe vera: A review. Journal of Herbal Medicine, v. 12, p. 1-10, 2018.
MARTINELLO, T. et al. Allogeneic mesenchymal stem cells improve the wound healing process of sheep skin. BMC veterinary research, v. 14, n. 1, p. 1-9, 2018.
MOHAMMADI, Zoheyr et al. The effect of chrysin–curcumin-loaded nanofibres on the wound-healing process in male rats. Artificial cells, nanomedicine, and biotechnology, v. 47, n. 1, p. 1642-1652, 2019.
ORYAN, Ahmad et al. Healing potential of injectable Aloe vera hydrogel loaded by adipose-derived stem cell in skin tissue-engineering in a rat burn wound model. Cell and tissue research, v. 377, n. 2, p. 215-227, 2019.
PARK, Jin Woo; HWANG, Seung Rim; YOON, In-Soo. Advanced growth factor delivery systems in wound management and skin regeneration. Molecules, v. 22, n. 8, p. 1259, 2017.
PARK, Ye Ri et al. NF-κB signaling is key in the wound healing processes of silk fibroin. Acta biomaterialia, v. 67, p. 183-195, 2018.
PIRES, Felipe Q. et al. Lipid nanoparticles as carriers of cyclodextrin inclusion complexes: A promising approach for cutaneous delivery of a volatile essential oil. Colloids and Surfaces B: Biointerfaces, v. 182, p. 110382, 2019.
PUGLIA, Carmelo; SANTONOCITO, Debora. Cosmeceuticals: Nanotechnology-Based Strategies for the Delivery of Phytocompounds. Current pharmaceutical design, v. 25, n. 21, p. 2314-2322, 2019.
SHI, Xiao-Dan et al. Structural and conformational characterization of linear O-acetyl-glucomannan purified from gel of Aloe barbadensis Miller. International journal of biological macromolecules, v. 120, p. 2373-2380, 2018.
SINGH, Shailendra; YOUNG, Alistair; MCNAUGHT, Clare-Ellen. The physiology of wound healing. Surgery (Oxford), v. 35, n. 9, p. 473-477, 2017.
SOARES, Margarida; VITORINO, Carla; SOUSA, João; PAIS, Alberto. Permeação cutânea: desafios e oportunidades. Revista de Ciências Farmacêuticas Básica e Aplicada, v. 36, n. 3, p. 337-348, 2015.
TESTER, Richard; AL-GHAZZEWI, Farage H. Role of glucomannans in immunology. Journal of Pharmacy & Pharmaceutical Sciences, v. 20, p. 97-114, 2017.
TIAN, Bingren et al. The application and prospects of cyclodextrin inclusion complexes and polymers in the food industry: A review. Polymer International, v. 69, n. 7, p. 597-603, 2020.
TOTTOLI, Erika Maria et al. Skin wound healing process and new emerging technologies for skin wound care and regeneration. Pharmaceutics, v. 12, n. 8, p. 735, 2020.
YANG, S. et al. Encapsulating plant ingredients for dermocosmetic application: An updated review of delivery systems and characterization techniques. International journal of cosmetic science, v. 42, n. 1, p. 16-28, 2020.
YOKOTA, Junko; KYOTANI, Shojiro. Influence of nanoparticle size on the skin penetration, skin retention and anti-inflammatory activity of non-steroidal anti-inflammatory drugs. Journal of the Chinese Medical Association, v. 81, n. 6, p. 511-519, 2018.
ZADEH GHARABOGHAZ, Morteza Najaf; FARAHPOUR, Mohammad Reza; SAGHAIE, Shahram. Topical co-administration of Teucrium polium hydroethanolic extract and Aloe vera gel triggered wound healing by accelerating cell proliferation in diabetic mouse model. Biomedicine & Pharmacotherapy, v. 127, p. 110189, 2020.
ZAREI, Farshad; SOLEIMANINEJAD, Maryam. Role of growth factors and biomaterials in wound healing. Artificial cells, nanomedicine, and biotechnology, v. 46, n. sup1, p. 906-911, 2018.
ZARZYCKI, Paweł K. et al. Cyclodextrins-based nanocomplexes for encapsulation of bioactive compounds in food, cosmetics, and pharmaceutical products: principles of supramolecular complexes formation, their influence on the antioxidative properties of target chemicals, and recent advances in selected industrial applications. Encapsulations, p. 717-767, 2016.
ZSIKÓ, Stella et al. Methods to evaluate skin penetration in vitro. Scientia Pharmaceutica, v. 87, n. 3, p. 19, 2019.
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