Keywords
Aloe vera
Glucomannan
Healing
Nanotechnology
Cyclodextrins
Glucomannan
Healing
Nanotechnology
Cyclodextrins
How to Cite
Fortes, C., & Ferreira de Barros Leite, N. . (2021). INCLUSION COMPLEXES OF CYCLODEXTRINS AND GLUCOMANNAN DERIVED FROM ALOE VERA IN THE DEVELOPMENT OF FORMULATIONS WITH HEALING ACTION. Advanced Studies on Health and Nature, 1. Retrieved from https://periodicojs.com.br/index.php/easn/article/view/301
Abstract
The various inconveniences caused by injuries, especially chronic wounds, represent one of the limitations of medicine today. Therefore, within the scope of alternatives for repairing tissue damage, several plant species are widely studied as a way to propose new therapies for the treatment of wounds, and among the species studied, Aloe vera is always a highlight. When observing these complications, significant efforts are made in order to seek new treatments and improvements in these therapies. One of the most promising alternatives that has become the focus of study in this area are delivery systems based on nanotechnology for the release of drugs and actives in a local and controlled manner. Given this, the present study aimed to conduct a literature review in order to correlate the possibility of applying Glucomannan derived from Aloe vera, complexed to cyclodextrins, as a delivery system for use in wound healing therapies. The Science Direct and Pubmed databases were used to survey the studies involving the chosen theme. Articles that directly addressed the established theme were included, involving experimental and clinical studies on the applications of A. vera and glucomannan in a nanostructured system for applications in tissue damage repair therapies. From the bibliographic survey carried out in the databases, a total of 30 articles were chosen for full reading, and in the end 25 studies were chosen to compose this research. The number of studies found as a whole from the searches with the chosen descriptors was quite expressive, presenting a significant amount of results. From this study, it can be stated that the continuity of research involving the use of glucomannan complexed to cyclodextrins is favorable, which implies good results.
References
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CHEN, Honglei et al. A novel wound dressing based on a Konjac glucomannan/silver nanoparticle composite sponge effectively kills bacteria and accelerates wound healing. Carbohydrate polymers, v. 183, p. 70-80, 2018.
ČUŘÍKOVÁ, Barbora Amélie et al. Simplified stratum corneum model membranes for studying the effects of permeation enhancers. International journal of pharmaceutics, v. 534, n. 1-2, p. 287-296, 2017.
DEBJIT, Bhowmik et al. Aloe vera-gift to mankind. International Journal of Minor Fruits, Medicinal and Aromatic Plants, v. 5, n. 1, p. 1-6, 2019.
DOLATI, Sanam et al. Prospects for the application of growth factors in wound healing. Growth Factors, v. 38, n. 1, p. 25-34, 2020.
ESSA, Rasha; MOHAMED, N.; KANDEEL, Hanan. Effect of aloe vera gel versus normal saline on pain relief and healing process of episiotomy. JHMN, v. 70, p. 66-81, 2020.
FERREIRA, J. F. S. Nanoencapsulation of essential oils for cosmetic application. Dissertação. Universidade de Coimbra. 2019.
GARCIA-ORUE, Itxaso et al. Composite nanofibrous membranes of PLGA/Aloe vera containing lipid nanoparticles for wound dressing applications. International journal of pharmaceutics, v. 556, p. 320-329, 2019.
GARCIA-ORUE, Itxaso et al. Nanotechnology-based delivery systems to release growth factors and other endogenous molecules for chronic wound healing. Journal of Drug Delivery Science and Technology, v. 42, p. 2-17, 2017.
GIANINO, Elizabeth; MILLER, Craig; GILMORE, Jordon. Smart wound dressings for diabetic chronic wounds. Bioengineering, v. 5, n. 3, p. 51, 2018.
GIRSANG, Rezky Sagita et al. Effect of Aloe vera Extracts towards the Fibroblast Number and Collagen Thickness on Clean Skin Wound Healing on Rattus Novergicus. Systematic Reviews in Pharmacy, v. 11, n. 5, p. 571-573, 2020.
HAMDAN, Suzana et al. Nanotechnology-driven therapeutic interventions in wound healing: potential uses and applications. ACS central science, v. 3, n. 3, p. 163-175, 2017.
HAN, George; CEILLEY, Roger. Chronic wound healing: a review of current management and treatments. Advances in therapy, v. 34, n. 3, p. 599-610, 2017
HAN, Hongwei; ROAN, Florence; ZIEGLER, Steven F. The atopic march: current insights into skin barrier dysfunction and epithelial cell‐derived cytokines. Immunological reviews, v. 278, n. 1, p. 116-130, 2017.
HUSEIN EL HADMED, Husein; CASTILLO, Rafael Fernandez. Cosmeceuticals: peptides, proteins, and growth factors. Journal of cosmetic dermatology, v. 15, n. 4, p. 514-519, 2016.
ISHIHARA, Jun et al. Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing. Nature communications, v. 9, n. 1, p. 1-14, 2018.
JUNQUEIRA, L. C.; CARNEIRO, José. Histologia básica. 13.ed. Rio de Janeiro: Guanabara Koogan, 2017
KHAVKIN, Jeannie; ELLIS, David AF. Aging skin: histology, physiology, and pathology. Facial Plastic Surgery Clinics, v. 19, n. 2, p. 229-234, 2011.
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KIM, Hyoung Ja et al. Concise synthesis of aloesone and aloesol natural products. Bulletin of the Korean Chemical Society, v. 38, n. 10, p. 1121-1122, 2017.
KIM, Yun Seop et al. Synergistic effects of hyaluronate–epidermal growth factor conjugate patch on chronic wound healing. Biomaterials science, v. 6, n. 5, p. 1020-1030, 2018.
KUMAR, Ramesh et al. Therapeutic potential of Aloe vera—A miracle gift of nature. Phytomedicine, v. 60, p. 152996, 2019.
KUMAR, V.; ABBAS, A.; FAUSTO, N. Robbins e Cotran – Patologia – Bases Patológicas das Doenças. 8. ed. Rio de Janeiro: Elsevier, 2010.
LI, Jun-yi et al. A systematic review exploring the anticancer activity and mechanisms of glucomannan. Frontiers in pharmacology, v. 10, p. 930, 2019.
MAAN, Abid Aslam et al. The therapeutic properties and applications of Aloe vera: A review. Journal of Herbal Medicine, v. 12, p. 1-10, 2018.
MARTINELLO, T. et al. Allogeneic mesenchymal stem cells improve the wound healing process of sheep skin. BMC veterinary research, v. 14, n. 1, p. 1-9, 2018.
MOHAMMADI, Zoheyr et al. The effect of chrysin–curcumin-loaded nanofibres on the wound-healing process in male rats. Artificial cells, nanomedicine, and biotechnology, v. 47, n. 1, p. 1642-1652, 2019.
ORYAN, Ahmad et al. Healing potential of injectable Aloe vera hydrogel loaded by adipose-derived stem cell in skin tissue-engineering in a rat burn wound model. Cell and tissue research, v. 377, n. 2, p. 215-227, 2019.
PARK, Jin Woo; HWANG, Seung Rim; YOON, In-Soo. Advanced growth factor delivery systems in wound management and skin regeneration. Molecules, v. 22, n. 8, p. 1259, 2017.
PARK, Ye Ri et al. NF-κB signaling is key in the wound healing processes of silk fibroin. Acta biomaterialia, v. 67, p. 183-195, 2018.
PIRES, Felipe Q. et al. Lipid nanoparticles as carriers of cyclodextrin inclusion complexes: A promising approach for cutaneous delivery of a volatile essential oil. Colloids and Surfaces B: Biointerfaces, v. 182, p. 110382, 2019.
PUGLIA, Carmelo; SANTONOCITO, Debora. Cosmeceuticals: Nanotechnology-Based Strategies for the Delivery of Phytocompounds. Current pharmaceutical design, v. 25, n. 21, p. 2314-2322, 2019.
SHI, Xiao-Dan et al. Structural and conformational characterization of linear O-acetyl-glucomannan purified from gel of Aloe barbadensis Miller. International journal of biological macromolecules, v. 120, p. 2373-2380, 2018.
SINGH, Shailendra; YOUNG, Alistair; MCNAUGHT, Clare-Ellen. The physiology of wound healing. Surgery (Oxford), v. 35, n. 9, p. 473-477, 2017.
SOARES, Margarida; VITORINO, Carla; SOUSA, João; PAIS, Alberto. Permeação cutânea: desafios e oportunidades. Revista de Ciências Farmacêuticas Básica e Aplicada, v. 36, n. 3, p. 337-348, 2015.
TESTER, Richard; AL-GHAZZEWI, Farage H. Role of glucomannans in immunology. Journal of Pharmacy & Pharmaceutical Sciences, v. 20, p. 97-114, 2017.
TIAN, Bingren et al. The application and prospects of cyclodextrin inclusion complexes and polymers in the food industry: A review. Polymer International, v. 69, n. 7, p. 597-603, 2020.
TOTTOLI, Erika Maria et al. Skin wound healing process and new emerging technologies for skin wound care and regeneration. Pharmaceutics, v. 12, n. 8, p. 735, 2020.
YANG, S. et al. Encapsulating plant ingredients for dermocosmetic application: An updated review of delivery systems and characterization techniques. International journal of cosmetic science, v. 42, n. 1, p. 16-28, 2020.
YOKOTA, Junko; KYOTANI, Shojiro. Influence of nanoparticle size on the skin penetration, skin retention and anti-inflammatory activity of non-steroidal anti-inflammatory drugs. Journal of the Chinese Medical Association, v. 81, n. 6, p. 511-519, 2018.
ZADEH GHARABOGHAZ, Morteza Najaf; FARAHPOUR, Mohammad Reza; SAGHAIE, Shahram. Topical co-administration of Teucrium polium hydroethanolic extract and Aloe vera gel triggered wound healing by accelerating cell proliferation in diabetic mouse model. Biomedicine & Pharmacotherapy, v. 127, p. 110189, 2020.
ZAREI, Farshad; SOLEIMANINEJAD, Maryam. Role of growth factors and biomaterials in wound healing. Artificial cells, nanomedicine, and biotechnology, v. 46, n. sup1, p. 906-911, 2018.
ZARZYCKI, Paweł K. et al. Cyclodextrins-based nanocomplexes for encapsulation of bioactive compounds in food, cosmetics, and pharmaceutical products: principles of supramolecular complexes formation, their influence on the antioxidative properties of target chemicals, and recent advances in selected industrial applications. Encapsulations, p. 717-767, 2016.
ZSIKÓ, Stella et al. Methods to evaluate skin penetration in vitro. Scientia Pharmaceutica, v. 87, n. 3, p. 19, 2019.
ALVES, Natália Cristina. Penetração de ativos na pele: revisão bibliográfica. Amazônia: science & health, v. 3, n. 4, p. 36 a 43-36 a 43, 2015.
BERNARDO, A. F. C.; SANTOS, K.; SILVA, D. P. Pele: alterações anatômicas e fisiológicas do nascimento à maturidade. Revista Saúde em Foco, v. 1, n. 11, p. 1221-33, 2019.
BRASILEIRO FILHO, G. Bogliolo - Patologia. 9. ed. Rio de Janeiro: Gen, Guanabara Koogan, 2016.
CARNEIRO, Simone Braga et al. Cyclodextrin–drug inclusion complexes: In vivo and in vitro approaches. International journal of molecular sciences, v. 20, n. 3, p. 642, 2019.
CHEN, Honglei et al. A novel wound dressing based on a Konjac glucomannan/silver nanoparticle composite sponge effectively kills bacteria and accelerates wound healing. Carbohydrate polymers, v. 183, p. 70-80, 2018.
ČUŘÍKOVÁ, Barbora Amélie et al. Simplified stratum corneum model membranes for studying the effects of permeation enhancers. International journal of pharmaceutics, v. 534, n. 1-2, p. 287-296, 2017.
DEBJIT, Bhowmik et al. Aloe vera-gift to mankind. International Journal of Minor Fruits, Medicinal and Aromatic Plants, v. 5, n. 1, p. 1-6, 2019.
DOLATI, Sanam et al. Prospects for the application of growth factors in wound healing. Growth Factors, v. 38, n. 1, p. 25-34, 2020.
ESSA, Rasha; MOHAMED, N.; KANDEEL, Hanan. Effect of aloe vera gel versus normal saline on pain relief and healing process of episiotomy. JHMN, v. 70, p. 66-81, 2020.
FERREIRA, J. F. S. Nanoencapsulation of essential oils for cosmetic application. Dissertação. Universidade de Coimbra. 2019.
GARCIA-ORUE, Itxaso et al. Composite nanofibrous membranes of PLGA/Aloe vera containing lipid nanoparticles for wound dressing applications. International journal of pharmaceutics, v. 556, p. 320-329, 2019.
GARCIA-ORUE, Itxaso et al. Nanotechnology-based delivery systems to release growth factors and other endogenous molecules for chronic wound healing. Journal of Drug Delivery Science and Technology, v. 42, p. 2-17, 2017.
GIANINO, Elizabeth; MILLER, Craig; GILMORE, Jordon. Smart wound dressings for diabetic chronic wounds. Bioengineering, v. 5, n. 3, p. 51, 2018.
GIRSANG, Rezky Sagita et al. Effect of Aloe vera Extracts towards the Fibroblast Number and Collagen Thickness on Clean Skin Wound Healing on Rattus Novergicus. Systematic Reviews in Pharmacy, v. 11, n. 5, p. 571-573, 2020.
HAMDAN, Suzana et al. Nanotechnology-driven therapeutic interventions in wound healing: potential uses and applications. ACS central science, v. 3, n. 3, p. 163-175, 2017.
HAN, George; CEILLEY, Roger. Chronic wound healing: a review of current management and treatments. Advances in therapy, v. 34, n. 3, p. 599-610, 2017
HAN, Hongwei; ROAN, Florence; ZIEGLER, Steven F. The atopic march: current insights into skin barrier dysfunction and epithelial cell‐derived cytokines. Immunological reviews, v. 278, n. 1, p. 116-130, 2017.
HUSEIN EL HADMED, Husein; CASTILLO, Rafael Fernandez. Cosmeceuticals: peptides, proteins, and growth factors. Journal of cosmetic dermatology, v. 15, n. 4, p. 514-519, 2016.
ISHIHARA, Jun et al. Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing. Nature communications, v. 9, n. 1, p. 1-14, 2018.
JUNQUEIRA, L. C.; CARNEIRO, José. Histologia básica. 13.ed. Rio de Janeiro: Guanabara Koogan, 2017
KHAVKIN, Jeannie; ELLIS, David AF. Aging skin: histology, physiology, and pathology. Facial Plastic Surgery Clinics, v. 19, n. 2, p. 229-234, 2011.
KIERZENBAUM, A. L.; TRES, L. L. Histologia e biologia celular: uma introdução à patologia. 4 ed. Rio de Janeiro: Elsevier, 2012.
KIM, Hyoung Ja et al. Concise synthesis of aloesone and aloesol natural products. Bulletin of the Korean Chemical Society, v. 38, n. 10, p. 1121-1122, 2017.
KIM, Yun Seop et al. Synergistic effects of hyaluronate–epidermal growth factor conjugate patch on chronic wound healing. Biomaterials science, v. 6, n. 5, p. 1020-1030, 2018.
KUMAR, Ramesh et al. Therapeutic potential of Aloe vera—A miracle gift of nature. Phytomedicine, v. 60, p. 152996, 2019.
KUMAR, V.; ABBAS, A.; FAUSTO, N. Robbins e Cotran – Patologia – Bases Patológicas das Doenças. 8. ed. Rio de Janeiro: Elsevier, 2010.
LI, Jun-yi et al. A systematic review exploring the anticancer activity and mechanisms of glucomannan. Frontiers in pharmacology, v. 10, p. 930, 2019.
MAAN, Abid Aslam et al. The therapeutic properties and applications of Aloe vera: A review. Journal of Herbal Medicine, v. 12, p. 1-10, 2018.
MARTINELLO, T. et al. Allogeneic mesenchymal stem cells improve the wound healing process of sheep skin. BMC veterinary research, v. 14, n. 1, p. 1-9, 2018.
MOHAMMADI, Zoheyr et al. The effect of chrysin–curcumin-loaded nanofibres on the wound-healing process in male rats. Artificial cells, nanomedicine, and biotechnology, v. 47, n. 1, p. 1642-1652, 2019.
ORYAN, Ahmad et al. Healing potential of injectable Aloe vera hydrogel loaded by adipose-derived stem cell in skin tissue-engineering in a rat burn wound model. Cell and tissue research, v. 377, n. 2, p. 215-227, 2019.
PARK, Jin Woo; HWANG, Seung Rim; YOON, In-Soo. Advanced growth factor delivery systems in wound management and skin regeneration. Molecules, v. 22, n. 8, p. 1259, 2017.
PARK, Ye Ri et al. NF-κB signaling is key in the wound healing processes of silk fibroin. Acta biomaterialia, v. 67, p. 183-195, 2018.
PIRES, Felipe Q. et al. Lipid nanoparticles as carriers of cyclodextrin inclusion complexes: A promising approach for cutaneous delivery of a volatile essential oil. Colloids and Surfaces B: Biointerfaces, v. 182, p. 110382, 2019.
PUGLIA, Carmelo; SANTONOCITO, Debora. Cosmeceuticals: Nanotechnology-Based Strategies for the Delivery of Phytocompounds. Current pharmaceutical design, v. 25, n. 21, p. 2314-2322, 2019.
SHI, Xiao-Dan et al. Structural and conformational characterization of linear O-acetyl-glucomannan purified from gel of Aloe barbadensis Miller. International journal of biological macromolecules, v. 120, p. 2373-2380, 2018.
SINGH, Shailendra; YOUNG, Alistair; MCNAUGHT, Clare-Ellen. The physiology of wound healing. Surgery (Oxford), v. 35, n. 9, p. 473-477, 2017.
SOARES, Margarida; VITORINO, Carla; SOUSA, João; PAIS, Alberto. Permeação cutânea: desafios e oportunidades. Revista de Ciências Farmacêuticas Básica e Aplicada, v. 36, n. 3, p. 337-348, 2015.
TESTER, Richard; AL-GHAZZEWI, Farage H. Role of glucomannans in immunology. Journal of Pharmacy & Pharmaceutical Sciences, v. 20, p. 97-114, 2017.
TIAN, Bingren et al. The application and prospects of cyclodextrin inclusion complexes and polymers in the food industry: A review. Polymer International, v. 69, n. 7, p. 597-603, 2020.
TOTTOLI, Erika Maria et al. Skin wound healing process and new emerging technologies for skin wound care and regeneration. Pharmaceutics, v. 12, n. 8, p. 735, 2020.
YANG, S. et al. Encapsulating plant ingredients for dermocosmetic application: An updated review of delivery systems and characterization techniques. International journal of cosmetic science, v. 42, n. 1, p. 16-28, 2020.
YOKOTA, Junko; KYOTANI, Shojiro. Influence of nanoparticle size on the skin penetration, skin retention and anti-inflammatory activity of non-steroidal anti-inflammatory drugs. Journal of the Chinese Medical Association, v. 81, n. 6, p. 511-519, 2018.
ZADEH GHARABOGHAZ, Morteza Najaf; FARAHPOUR, Mohammad Reza; SAGHAIE, Shahram. Topical co-administration of Teucrium polium hydroethanolic extract and Aloe vera gel triggered wound healing by accelerating cell proliferation in diabetic mouse model. Biomedicine & Pharmacotherapy, v. 127, p. 110189, 2020.
ZAREI, Farshad; SOLEIMANINEJAD, Maryam. Role of growth factors and biomaterials in wound healing. Artificial cells, nanomedicine, and biotechnology, v. 46, n. sup1, p. 906-911, 2018.
ZARZYCKI, Paweł K. et al. Cyclodextrins-based nanocomplexes for encapsulation of bioactive compounds in food, cosmetics, and pharmaceutical products: principles of supramolecular complexes formation, their influence on the antioxidative properties of target chemicals, and recent advances in selected industrial applications. Encapsulations, p. 717-767, 2016.
ZSIKÓ, Stella et al. Methods to evaluate skin penetration in vitro. Scientia Pharmaceutica, v. 87, n. 3, p. 19, 2019.
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