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Abstract
Introduction: Microchimerism is characterized by the bidirectional exchange of cells between mother and fetus during pregnancy, which may also originate in processes such as childbirth and abortion. Feto-maternal microchimerism refers to the population of cells of fetal origin residing in the maternal organism, where they have been observed acting in different ways, such as in cutaneous tissue repair. Objectives: To review the availability of scientific evidence in the literature on the role of cells of fetal origin in the maternal skin healing process, and their benefits and harms for the restitution and maintenance of skin homeostasis. Material and methods: Based on the acronym PICO, a integrative literature review was performed using the PRISMA method to search the literature by descriptors and mesh terms related to microchimerism and skin healing. Results: 57 records of articles deemed relevant for this work were found in the two platforms used, 41 of which were found in PubMed and 16 in Google Scholar. After pre-selection by reading the titles and abstracts, 50 articles were excluded by applying the eligibility criteria. 16 articles dealing individually with microchimerism or skin scarring. Finally, 7 articles were selected for full reading, and 2 of them were discarded for not presenting enough information for review. The reviewed articles (n=5) showed proliferative and phenotypic differentiation activities of microchimeric cells in response to maternal injury, and offered a basis for applications in regenerative therapy. Conclusion: Despite the active participation of fetal-maternal microchimeric cells in maternal skin healing, and the therapeutic potential, further experimental studies are needed to understand their role for future applications in regenerative therapy.
References
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