Abstract
Introduction: Chagas disease has become increasingly important due to the large number of people infected and living in endemic areas. It is also considered a neglected disease, because it affects people of low socioeconomic level, and thus generate a minor stimulus in drug research. Drugs currently used are poorly effective in the chronic phase of the disease. Objective: To analyze the last articles of the literature regarding the treatment of American Trypanosomiasis. Methodology: This is an integrative review of the literature, with the searches being carried out in the databases: Latin American and Caribbean Literature in Health Sciences (LILACS), Scientific Electronic Library Online (SciELO) and PubMed. The following descriptors were used cross-sectional: “Chagas disease” and “treatment”, and studies published between 2012 and 2017 were analyzed. Results: After applying inclusion and exclusion criteria, 5 studies were selected for analysis. Discussion: The use of posaconazole, alone or in combination with benzonidazole, in the chronic form of the disease was evaluated in two studies, with results demonstrating its insufficiency. The association between benzonidazole and allopurinol has also been studied and promising results have been obtained. The use of benzonidazole was tested in cardiac form, obtaining results similar to placebo. The administration of omega-3 in cardiac form, obtained promising effects. Conclusion: New possibilities of drug associations and development were found in the present study.
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