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Abstract
Epilepsy, a common neurological disorder, has been associated with an increased risk of cardiogenic complications, including arrhythmias, acute myocardial infarction, heart failure, and sudden unexpected death in epilepsy (SUDEP). Large epidemiological studies reveal a significantly higher prevalence of arrhythmias (5-10%) and a 2.3-fold increased risk of infarction in patients with epilepsy compared to the general population. The pathophysiology of this correlation is complex, involving dysautonomia, neuroinflammation, cardiotoxic effects of antiepileptic drugs, and electrolyte disturbances. The clinical implications are significant, requiring a multidisciplinary approach in the management of patients with epilepsy, including cardiovascular assessment and monitoring, optimization of antiepileptic treatment, and promotion of healthy lifestyle habits. Future research should focus on elucidating the molecular mechanisms of SUDEP, the role of neuroinflammation in atherosclerosis, the impact of different types of epilepsy, and the long-term effects of antiepileptic treatment.
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