Abstract
Considered a respiratory infection, COVID-19 can lead to neurological pathologies, including encephalitis, stroke, acute disseminated encephalomyelitis and peripheral neuropathies, such as Guillain-Barré syndrome. Guillain-Barré syndrome, also known as acute polyradiculoneuropathy, is an autoimmune disease of the nervous system. Its main manifestation is the acute inflammation of the nerves and nerve roots, attacking the myelin sheath. Bearing in mind the relationship between neurological disorders and COVID-19, the doctor can adopt the best approach for each case, knowing that the neurological manifestations of COVID-19 are varied and that the data on them continue to evolve as the pandemic progresses.
References
Hatmi, Z.N. A Systematic Review of Systematic Reviews on the COVID-19 Pandemic. SN Compr. Clin.
Med. 3, 419–436 (2021). https://doi.org/10.1007/s42399-021-00749-y
Arca, K.N., Starling, A.J. Treatment-Refractory Headache in the Setting of COVID-19 Pneumonia: Migraine
or Meningoencephalitis? Case Report. SN Compr. Clin. Med. 2, 1200–1203 (2020).
https://doi.org/10.1007/s42399-020-00369-y
Duyan, M., Ozturan, I.U. & Altas, M. Delayed Parosmia Following SARS-CoV-2 Infection: a Rare Late
Complication of COVID-19. SN Compr. Clin. Med. 3, 1200–1202 (2021). https://doi.org/10.1007/s42399-
021-00876-6
Cerasti, D., Ormitti, F., Pardatscher, S. et al. Multiple Acute Ischemic Strokes in a COVID-19 Patient: a
Case Report. SN Compr. Clin. Med. 2, 1213–1217 (2020). https://doi.org/10.1007/s42399-020-00388-9
Martelletti, P., Bentivegna, E., Luciani, M. et al. Headache as a Prognostic Factor for COVID-19. Time to
Re-evaluate. SN Compr. Clin. Med. 2, 2509–2510 (2020). https://doi.org/10.1007/s42399-020-00657-7
Emmerton, D., Abdelhafiz, A. Delirium in Older People with COVID-19: Clinical Scenario and
Literature Review. SN Compr. Clin. Med. 2, 1790–1797 (2020). https://doi.org/10.1007/s42399-
020-00474-y
Yeganegi, M., Fattahi, P. Management and Prevention of Cerebrovascular Accidents in SARS-CoV-
2–Positive Patients Recovering from COVID-19: a Case Report and Review of Literature. SN Compr. Clin.
Med. 3, 279–290 (2021). https://doi.org/10.1007/s42399-021-00744-3
Padda, I., Khehra, N., Jaferi, U. et al. The Neurological Complexities and Prognosis of COVID-19. SN
Compr. Clin. Med. 2, 2025–2036 (2020). https://doi.org/10.1007/s42399-020-00527-2
Alshebri, M.S., Alshouimi, R.A., Alhumidi, H.A. et al. Neurological Complications of SARS-CoV, MERS-
CoV, and COVID-19. SN Compr. Clin. Med. 2, 2037–2047 (2020). https://doi.org/10.1007/s42399-020-
00589-2
Egilmez, O.K., Gündoğan, M.E., Yılmaz, M.S. et al. Can COVID-19 Cause Peripheral Facial Nerve
Palsy?. SN Compr. Clin. Med. (2021). https://doi.org/10.1007/s42399-021-00967-4
Kajumba, M.M., Kolls, B.J., Koltai, D.C. et al. COVID-19-Associated Guillain-Barre Syndrome: Atypical
Para-infectious Profile, Symptom Overlap, and Increased Risk of Severe Neurological Complications. SN
Compr. Clin. Med. 2, 2702–2714 (2020). https://doi.org/10.1007/s42399-020-00646-w
Fatehi, P., Hesam-Shariati, N., Abouzaripour, M. et al. Acute Ischemic and Hemorrhagic Stroke and
COVID-19: Case Series. SN Compr. Clin. Med. 2, 2396–2401 (2020). https://doi.org/10.1007/s42399-020-
00559-8
Gutierrez Amezcua, J., Jain, R., Kleinman, G. et al. COVID-19-Induced Neurovascular Injury: a
Case Series with Emphasis on Pathophysiological Mechanisms. SN Compr. Clin.
Med. 2, 2109–2125 (2020). https://doi.org/10.1007/s42399-020-00598-1
Bao, Y., Lin, S.Y., Cheng, Z.H. et al. Clinical Features of COVID-19 in a Young Man with Massive Cerebral
Hemorrhage—Case Report. SN Compr. Clin. Med. 2, 703–709 (2020). https://doi.org/10.1007/s42399-020-
00315-y
Martelletti, P., Bentivegna, E., Spuntarelli, V. et al. Long-COVID Headache. SN Compr. Clin. Med. (2021).
https://doi.org/10.1007/s42399-021-00964-7
Jakhmola, S., Indari, O., Chatterjee, S. et al. SARS-CoV-2, an Underestimated Pathogen of the Nervous
System. SN Compr. Clin. Med. 2, 2137–2146 (2020). https://doi.org/10.1007/s42399-020-00522-7
de Francisco Moure, J., Torres Ramón, I. & Almárcegui Lafita, C. Acute Polyneuropathy in an Outpatient
Context During the SARS-CoV-2 Pandemic: A Brief Case Serie Report. SN Compr. Clin.
Med. 3, 1182–1184 (2021). https://doi.org/10.1007/s42399-021-00855-x
Maxime Taquet, John R Geddes, Masud Husain, Sierra Luciano, Paul J Harrison 6-month neurological and psychiatric
outcomes in 236379 survivors of COVID-19: a retrospective cohort study using electronic health records
Jaqueline S. Generoso, João L. Barichello de Quevedo, 1 Matias Cattani, 1 Bruna F. Lodetti, 1 Lucas Sousa, 1 Allan
Collodel, Alexandre P. Diaz, Felipe Dal-Pizzol Neurobiology of COVID-19: how can the virus affect the brain?
Madhu Jasti1 · Krishna Nalleballe2 · Vasuki Dandu2 · Sanjeeva Onteddu2 A review of pathophysiology
and neuropsychiatric manifestations of COVID19
Haiyang Yu1 , Tong Sun2 and Juan Feng1 Complications and Pathophysiology of COVID-19 in the Nervous System
Med. 3, 419–436 (2021). https://doi.org/10.1007/s42399-021-00749-y
Arca, K.N., Starling, A.J. Treatment-Refractory Headache in the Setting of COVID-19 Pneumonia: Migraine
or Meningoencephalitis? Case Report. SN Compr. Clin. Med. 2, 1200–1203 (2020).
https://doi.org/10.1007/s42399-020-00369-y
Duyan, M., Ozturan, I.U. & Altas, M. Delayed Parosmia Following SARS-CoV-2 Infection: a Rare Late
Complication of COVID-19. SN Compr. Clin. Med. 3, 1200–1202 (2021). https://doi.org/10.1007/s42399-
021-00876-6
Cerasti, D., Ormitti, F., Pardatscher, S. et al. Multiple Acute Ischemic Strokes in a COVID-19 Patient: a
Case Report. SN Compr. Clin. Med. 2, 1213–1217 (2020). https://doi.org/10.1007/s42399-020-00388-9
Martelletti, P., Bentivegna, E., Luciani, M. et al. Headache as a Prognostic Factor for COVID-19. Time to
Re-evaluate. SN Compr. Clin. Med. 2, 2509–2510 (2020). https://doi.org/10.1007/s42399-020-00657-7
Emmerton, D., Abdelhafiz, A. Delirium in Older People with COVID-19: Clinical Scenario and
Literature Review. SN Compr. Clin. Med. 2, 1790–1797 (2020). https://doi.org/10.1007/s42399-
020-00474-y
Yeganegi, M., Fattahi, P. Management and Prevention of Cerebrovascular Accidents in SARS-CoV-
2–Positive Patients Recovering from COVID-19: a Case Report and Review of Literature. SN Compr. Clin.
Med. 3, 279–290 (2021). https://doi.org/10.1007/s42399-021-00744-3
Padda, I., Khehra, N., Jaferi, U. et al. The Neurological Complexities and Prognosis of COVID-19. SN
Compr. Clin. Med. 2, 2025–2036 (2020). https://doi.org/10.1007/s42399-020-00527-2
Alshebri, M.S., Alshouimi, R.A., Alhumidi, H.A. et al. Neurological Complications of SARS-CoV, MERS-
CoV, and COVID-19. SN Compr. Clin. Med. 2, 2037–2047 (2020). https://doi.org/10.1007/s42399-020-
00589-2
Egilmez, O.K., Gündoğan, M.E., Yılmaz, M.S. et al. Can COVID-19 Cause Peripheral Facial Nerve
Palsy?. SN Compr. Clin. Med. (2021). https://doi.org/10.1007/s42399-021-00967-4
Kajumba, M.M., Kolls, B.J., Koltai, D.C. et al. COVID-19-Associated Guillain-Barre Syndrome: Atypical
Para-infectious Profile, Symptom Overlap, and Increased Risk of Severe Neurological Complications. SN
Compr. Clin. Med. 2, 2702–2714 (2020). https://doi.org/10.1007/s42399-020-00646-w
Fatehi, P., Hesam-Shariati, N., Abouzaripour, M. et al. Acute Ischemic and Hemorrhagic Stroke and
COVID-19: Case Series. SN Compr. Clin. Med. 2, 2396–2401 (2020). https://doi.org/10.1007/s42399-020-
00559-8
Gutierrez Amezcua, J., Jain, R., Kleinman, G. et al. COVID-19-Induced Neurovascular Injury: a
Case Series with Emphasis on Pathophysiological Mechanisms. SN Compr. Clin.
Med. 2, 2109–2125 (2020). https://doi.org/10.1007/s42399-020-00598-1
Bao, Y., Lin, S.Y., Cheng, Z.H. et al. Clinical Features of COVID-19 in a Young Man with Massive Cerebral
Hemorrhage—Case Report. SN Compr. Clin. Med. 2, 703–709 (2020). https://doi.org/10.1007/s42399-020-
00315-y
Martelletti, P., Bentivegna, E., Spuntarelli, V. et al. Long-COVID Headache. SN Compr. Clin. Med. (2021).
https://doi.org/10.1007/s42399-021-00964-7
Jakhmola, S., Indari, O., Chatterjee, S. et al. SARS-CoV-2, an Underestimated Pathogen of the Nervous
System. SN Compr. Clin. Med. 2, 2137–2146 (2020). https://doi.org/10.1007/s42399-020-00522-7
de Francisco Moure, J., Torres Ramón, I. & Almárcegui Lafita, C. Acute Polyneuropathy in an Outpatient
Context During the SARS-CoV-2 Pandemic: A Brief Case Serie Report. SN Compr. Clin.
Med. 3, 1182–1184 (2021). https://doi.org/10.1007/s42399-021-00855-x
Maxime Taquet, John R Geddes, Masud Husain, Sierra Luciano, Paul J Harrison 6-month neurological and psychiatric
outcomes in 236379 survivors of COVID-19: a retrospective cohort study using electronic health records
Jaqueline S. Generoso, João L. Barichello de Quevedo, 1 Matias Cattani, 1 Bruna F. Lodetti, 1 Lucas Sousa, 1 Allan
Collodel, Alexandre P. Diaz, Felipe Dal-Pizzol Neurobiology of COVID-19: how can the virus affect the brain?
Madhu Jasti1 · Krishna Nalleballe2 · Vasuki Dandu2 · Sanjeeva Onteddu2 A review of pathophysiology
and neuropsychiatric manifestations of COVID19
Haiyang Yu1 , Tong Sun2 and Juan Feng1 Complications and Pathophysiology of COVID-19 in the Nervous System
Downloads
Download data is not yet available.
Metrics
Metrics Loading ...