Abstract
Objective: Advances in understanding the pathophysiology of Covid-19 identify the need to adapt the management, in order to correspond to its specificity. In this way, the largest organ in the human body becomes the target of manifestations in a significant part of those infected by Sars-Cov-2. Method: A literature review was carried out on PubMed platforms with the descriptors “Covid 19”, “Manifestations”, and “Skin” and Lilacs with the descriptors “Covid 19” and “skin”. From the results obtained, articles that elucidated dermatological manifestations were selected. Results and Discussion: The skin lesions most frequently related to Covid-19 were rash, erythema, exanthema, papules, vesicles, petechiae and hives. Conclusion: It is still not possible to state that skin lesions, in isolation, are an indicator of disease severity, however, lesions with vascular involvement tend to have a worse prognosis, deserving differentiated systemic attention, due to their greater potential for severity.
References
Singh H, Kaur H, Singh K, Sen CK. Cutaneous Manifestations of COVID-19: A Systematic Review. Adv Wound Care (New Rochelle). 2021 Feb;10(2):51-80. doi: 10.1089/wound.2020.1309. Epub 2020 Oct 19. PMID: 33035150; PMCID: PMC8020517.
Zhao Q, Fang X, Pang Z, Zhang B, Liu H, Zhang F. COVID-19 and cutaneous manifestations: a systematic review. J Eur Acad Dermatol Venereol. 2020 Nov;34(11):2505-2510. doi: 10.1111/jdv.16778. Epub 2020 Aug 26. PMID: 32594572; PMCID: PMC7361780.
Perna A, Passiatore M, Massaro A, Terrinoni A, Bianchi L, Cilli V, D’Orio M, Proietti L, Taccardo G, De Vitis R. Skin manifestations in COVID-19 patients, state of the art. A systematic review. Int J Dermatol. 2021 May;60(5):547-553. doi: 10.1111/ijd.15414. Epub 2021 Feb 2. PMID: 33533036; PMCID: PMC8014166.
de Souza TH, Nadal JA, Nogueira RJN, Pereira RM, Brandão MB. Clinical manifestations of children with COVID-19: A systematic review. Pediatr Pulmonol. 2020 Aug;55(8):1892-1899. doi: 10.1002/ppul.24885. Epub 2020 Jun 15. PMID: 32492251; PMCID: PMC7300659.
Seirafianpour F, Sodagar S, Pour Mohammad A, Panahi P, Mozafarpoor S, Almasi S, Goodarzi A. Cutaneous manifestations and considerations in COVID-19 pandemic: A systematic review. Dermatol Ther. 2020 Nov;33(6):e13986. doi: 10.1111/dth.13986. Epub 2020 Aug 6. PMID: 32639077; PMCID: PMC7362033.
Conforti C, Dianzani C, Agozzino M, Giuffrida R, Marangi GF, Meo ND, Morariu SH, Persichetti P, Segreto F, Zalaudek I, Neagu N. Cutaneous Manifestations in Confirmed COVID-19 Patients: A Systematic Review. Biology (Basel). 2020 Dec 5;9(12):449. doi: 10.3390/biology9120449. PMID: 33291502; PMCID: PMC7762103.
Jamshidi P, Hajikhani B, Mirsaeidi M, Vahidnezhad H, Dadashi M, Nasiri MJ. Skin Manifestations in COVID-19 Patients: Are They Indicators for Disease Severity? A Systematic Review. Front Med (Lausanne). 2021 Feb 16;8:634208. doi: 10.3389/fmed.2021.634208. PMID: 33665200; PMCID: PMC7921489.
Li H, Zhao Y, Zhou L, Hu J. Cutaneous, skin histopathological manifestations and relationship to COVID-19 infection patients. Dermatol Ther. 2020 Nov;33(6):e14157. doi: 10.1111/dth.14157. Epub 2020 Sep 7. PMID: 32770717; PMCID: PMC7435499.
Sameni F, Hajikhani B, Yaslianifard S, Goudarzi M, Owlia P, Nasiri MJ, Shokouhi S, Bakhtiyari M, Dadashi M. COVID-19 and Skin Manifestations: An Overview of Case Reports/Case Series and Meta-Analysis of Prevalence Studies. Front Med (Lausanne). 2020 Oct 29;7:573188. doi: 10.3389/fmed.2020.573188. PMID: 33224961; PMCID: PMC7668416.
Erbaş GS, Botsali A, Erden N, Arı C, Taşkın B, Alper S, Vural S. COVID-19-related oral mucosa lesions among confirmed SARS-CoV-2 patients: a systematic review. Int J Dermatol. 2022 Jan;61(1):20-32. doi: 10.1111/ijd.15889. Epub 2021 Sep 22. PMID: 34549816; PMCID: PMC8652904.
A case of COVID-19 with papulovesicular rash that progressed to retiform purpura, accompanied by cherry angiomas.Agirgol, Senay; Çaytemel, Ceyda; Kolan, Ahmet Şah; Vural, Hüseyin. Säo Paulo med. j ; 139(2): 186-189, Mar.-Apr. 2021.
New papulovesicular rash in the course of COVID-19 signaling viral reactivation. Rihl, Marcos Frata; Fendt, Lúcia Costa Cabral; Nedel, Wagner Luis. Rev. Assoc. Med. Bras. (1992) ; 67(2): 182-184, Feb. 2021.
Petechial lesions in a patient with COVID-19 Fujimoto, Luciana Botinelly Mendonça; Ferreira, Silvana de Albuquerque Damasceno; Santos, Fabiane Braga dos; Talhari, Carolina. An. bras. dermatol ; 96(1): 111-113, Jan.-Feb. 2021.
Diffuse skin rash in tropical areas: Dengue fever or COVID-19? Pastor Bandeira, Isabelle; Sordi Chara, Beatriz; Meneguzzi de Carvalho, Giovani; Magno Gonçalves, Marcus Vinícius. An. bras. dermatol ; 96(1): 85-87, Jan.-Feb. 2021.
COVID-19 presenting as a viral exanthem and detected during admission prescreening in a hematopoietic cell transplant recipiente Ahmed, Nausheen; Lima, Marcos de; Rohr, Bethany R; Tomlinson, Benjamin K. Hematol., Transfus. Cell Ther. (Impr.) ; 42(3): 215-217, July-Sept. 2020.
COVID-19 presenting as an exanthematic disease: a case report Aragão, Matheus Todt; Santos Júnior, Eusébio Lino dos; Ataide, Tainah Dantas; Alves Neto, José Seabra; Aragão, Nathalia Vasconcelos Barroso Todt. Rev. Soc. Bras. Med. Trop ; 53: e20200533, 2020.
Exantema asociado a COVID-19 / COVID-19 skin rash Fernández Pardal, Patricia Analía; Leiro, Viviana; Alvaro, Yasmin Nicole; Iglesias Leal, Camila; del Valle Rueda, María; Villanueva Bruce, Carola; Maronna, Esteban; Mammana, Lilia; Carranza, José Ignacio; Olivares, Liliana María.
Actual. SIDA. infectol ; 28(104): 141-146, 2020.
Manifestaciones cutáneas en pacientes pediátricos infectados por el coronavirus SARS-CoV-2 / Cutaneous manifestations in pediatric patients infected with SARS-CoV-2 coronavirus Granados Campos, Lilian; Broche del Pino, Lorenzo; Pérez Leal, Lizzi; López Rodríguez, Vania María. Rev. cuba. pediatr ; 92(supl.1): e1171, 2020.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2023 Amanda Araujo Hottz Klein, Katriel Proença Benacchio