Keywords
How to Cite
Abstract
Introduction First isolated by Karl Meyer and John Palmer in 1934, but described only in 1970 by Laurent, Hyaluronic acid has become a source of several researches in biochemistry as a potential molecule for dermal restructuring and filling in the specialty of Orofacial Harmonization, and like any other substance injected into the human body, is capable of causing, although infrequent, the so-called adverse events. Objective The objective of this narrative review is to report the main adverse effects associated with the use of Hyaluronic acid, as well as its prevention and treatment. Methodology A bibliographic survey was carried out in the Scielo, PubMed and LILACS databases with the following terms: “Hyaluronic acid” and “adverse events”, and by crossing the Boolean descriptors <and> and <or>, the relationship between expressions. Results There was little reference in the literature regarding the frequency of adverse events associated with the use of Hyaluronic acid, but despite being little present, the professional’s knowledge, about how they occur, how to prevent and treat them, is necessary for the clinical practice of the dental surgeon specialized in Orofacial Harmonization.
References
Abatangelo G, Vindigni V, Avruscio G, Pandis L, Brun P. Hyaluronic Acid: Redefining Its Role. Cells. 9(7):1743. 2021.
Bukhari SNA, Roswandi NL, Waqas M, et al. Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects. Int J Biol Macromol. 120(Pt B):1682-1695. 2018.
Castro MB, Alcântara GA. Efeitos adversos no uso do ácido hialurônico injetável em preenchimentos faciais. Brazilian Journal of Health Review. v.3, n.2, p.2995-3005. 2020.
ISAPS. Mais recente estudo internacional demonstra crescimento mundial em cirurgia estética. A Sociedade Internacional de Cirurgia Plástica Estética [boletim informativo], 2018. Disponível em: <https://www.isaps.org/wp-content/uploads/2018/11/2017-Global-Survey-Press-Release-br.pdf>. Acesso em: 28 de março de 2022.
Harrer D, Sanchez Armengol E, Friedl JD, et al. Is hyaluronic acid the perfect excipient for the pharmaceutical need?. Int J Pharm. 601:120589. 2021.
Fallacara A, Baldini E, Manfredini S, Vertuani S. Hyaluronic acid in the third millennium. Polymers (Basel). 10(7), 701. 2018.
Brown MB, Jones AS. Hyaluronic acid: A unique topical vehicle for the localized delivery of drugs to the skin. J. Eur. Acad. Dermatology Venereol. 19(3), 308–318. 2005.
Juncan AM, Moisă DG, Santini A, et al. Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals. Molecules. 26(15):4429. 2021.
Liao YH, Jones SA, Forbes B, Martin GP, Brown MB. Hyaluronan: Pharmaceutical characterization and drug delivery. Drug Deliv. J. Deliv. Target. Ther. Agents. 12, 327–342. 2005.
Kakehi K, Kinoshita M, Yasueda SI. Hyaluronic acid: Separation and biological implications. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 797, 347–355. 2003.
Bukhari NS, Roswandi NL, Waqas M, Habib H, Hussain F, Khan S, Sohail M, Ramli NA, Thu HE, Hussain Z. Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects. Int. J. Biol. Macromol. 1682–1695. 2018.
Pavicic T, Gauglitz GG, Lersch P, Schwach-Abdellaoui K, Malle B, Korting HC, Farwick M. Efficacy of Cream-Based Novel Formulations of Hyaluronic Acid of Different Molecular Weights in Anti-Wrinkle Treatment. J. Drugs Dermatol. 10, 990–1000. 2011.
Souto EB, Fernandes AR, Martins-Gomes C, Coutinho TE, Durazzo A, Lucarini M, Souto SB, Silva AM, Santini A. Nanomaterials for skin delivery of cosmeceuticals and pharmaceuticals. Appl. Sci. 10, 1594. 2020.
Juncan AM, Visioline VL. The Images of Skin Texture before Product Application (D0) and after 28 Days (D28); Report No. 300924/19/JSHR Table 3; Courage+Khazaka Electronic GmbH: Köln, Germany. 2019.
Virchow RLK. Cellular Pathology: As Based Upon Physiological and Pathological Histology, 2 ed., London, John Churchill. 1860.
Abdayem R, Haftek M. Barrière épidermique. Ann Dermatol Venereol. 2018.
Magalhães BR. Processos degenerativos do tecido cutâneo: fisiologia, prevenção e tratamento. Universidade Fernando Pessoa. Porto, 2016.
Oliveira R, Santos D. Sistemas Transdérmicos. In: Souto, E. B. e Lopes, C. M. (Eds.). Novas Formas Farmacêuticas para Administração de Fármacos. Porto, Edições Universidade Fernando Pessoa, pp. 152-153. 2011.
Hunter JAA, Savin JÁ, Dahl MV. Clinical Dermatology, 3 ed., Oxford, Blackwell Publishing. 2002.
Gawkrodger DJ. Dermatology: An Illustrated Colour Text, 3 ed., Edinburgh, Churchill Livingstone. 2002.
Azulay RD, Azulay DR. A pele – embriologia, estrutura e fisiologia. Dermatologia (Revisada e atualizada), 2a edição, Editora Guanabara Koogan, Capítulo 1, pp. 1-10. 1999.
Ruivo AP. Envelhecimento Cutâneo: fatores influentes, ingredientes ativos e estratégias de veiculação. Universidade Fernando Pessoa. 2014.
Barbosa FS. Modelo de Impedância de Ordem Fracional para a Resposta Inflamatória Cutânea. Universidade Federal do Rio de Janeiro. 2011.
Prista LN. Administração de medicamentos. In: Prista LN. et al. (Eds.). Tecnologia Farmacêutica - I volume. Lisboa, Fundação Calouste Gulbenkian, pp. 93-98. 2011.
Monteiro E.O. Complicações imediatas com preenchimento cutâneo - Revista Brasileira de Medicina – Editora Moreira Jr. 14 V71 n.esp. Cosmiatria. 2010.
Gerson J. Fundamentos da Estética. volume 3. 10ª ed. Norte-americana Miladys Standard: Cenage Learning Edições Ltda. São Paulo. p. 03, 04.19. 2011.
Teston AP, Nardino D, Pivato L. Envelhecimento cutâneo: teoria dos radicais livres e tratamentos visando a prevenção e o rejuvenescimento. Revista Uningá Review, v.1, n.1, out. 2017.
Balasiano LKA, Bravo BSF. Hialuronidase: uma necessidade de todo dermatologista que aplica ácido hialurônico injetável. Surg Cosmet Dermatol. v.4. 2014.
Signorini M, et al. Global aesthetics consensus: Avoidance and management of complications from hyaluronic acid fillers: evidence, and opinion, based review and consensus recommendations - Plast Reconstr Surg. 137 (6): 961971. 2016.
Oliveira EA, Alessi RC. Eventos adversos do ácido hialurônico injetável. Surgical & Cosmetic Dermatology. vol. 4, núm. 3, 2012, pp. 259-263. 2012.
Rizo-Potau D, Marti-Marti I, Fustà-Novell X. Erythema multiforme. Eritema multiforme. Med Clin (Barc). 156(10):533. 2021.
Fujihara T, Ishida R, Yamamori Y. A case of lip edema caused by the accidental ingestion of a bar of soap. Clin Case Rep. 9(7):e04484. 2021.
Moraes BR, Bonami JÁ, Romualdo L. Ácido Hialurônico dentro da Área de Estética e Cosmética. Revista Saúde em Foco – Edição nº 9. 2017.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2023 Mariela Talarico Folco, Roberto Teruo Suguihara, Daniella Pilon Muknicka