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Abstract
Introduction: Myocarditis, an inflammation of the heart muscle, can arise as a complication of dengue fever, a mosquito-borne disease. It is essential to adopt a multidisciplinary approach to monitor and treat cardiac complications in patients with dengue fever at an early stage. Diagnostic tests include serology, PCR, and echocardiography. From a review study on cardiac involvement in dengue, it was found that this complication is significant and demands a multidisciplinary approach . Objective: The objective of this study was to conduct a comprehensive integrative review to explore the relationship between myocarditis and dengue fever. Methodology: Articles were searched in databases such as PubMed, Google Scholar,Ministry of Health, and ScienceDirect, using search terms in both Portuguese and English. Out of 122 articles found, 74 were selected for analysis, and 13 were included in the results. Results: The studies examined the relationship between dengue fever and myocarditis, with a focus on the cardiovascular manifestations of dengue fever and the prevalence of myocarditis in infected patients. Analysis of the articles revealed a significant prevalence of myocarditis in patients with dengue, highlighting a strong association between the two conditions. Discussion: Dengue patients frequently present with cardiac issues such as myocarditis, necessitating early detection to prevent serious complications. Effective vector control is crucial to reducing the impact of dengue. These findings provide direction for future research and the development of targeted therapies. Conclusion: Early identification of cardiac complications, such as myocarditis in dengue patients, is crucial to reducing morbidity and mortality. Ongoing research into the pathophysiological mechanisms is vital for the development of specific treatments. The study concludes that myocarditis is commonly associated with dengue, requiring meticulous medical monitoring.
References
Araiza-Garaygordobil D, et al. Dengue and the heart. Cardiovasc J Afr. 2021;32(5):276-83. doi: 10.5830/CVJA-2021-033. Epub 2021 Jul 20. PMID: 34292294; PMCID: PMC8756038.
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Departamento de Doenças Transmissíveis. Dengue : diagnóstico e manejo clínico : adulto e criança [recurso eletrônico] / Ministério da Saúde, Secretaria de Vigilância em Saúde e Ambiente, Departamento de Doenças Transmissíveis. – 6. ed. – Brasília : Ministério da Saúde, 2024.Disponivel em: file:///C:/Users/rafae/Downloads/Manejo%20clinico%20da%20Dengue.pdf
Bai C, Wang R, Xiong Q, Yang Q, Han P. Dengue virus infection induces myocarditis in IFNα/β receptor deficient mice. Mol Biomed. 2023;4(1):36. doi: 10.1186/s43556-023-00150-2. PMID: 37903980; PMCID: PMC10616043.
Baqi A, Rehman Fu, Memon PS, Omair SF. Prevalence and outcomes of myocarditis in dengue-infected patients admitted to a tertiary care hospital of low-middle income country. Glob Heart. 2022;17(1):44. doi: 10.5334/gh.1129.
Bhatt M, et al. Myocarditis in admitted patients with dengue fever. Infection. 2020;48(6):899-903. doi: 10.1007/s15010-020-01500-w. Epub 2020 Aug 11. PMID: 32780310.
Buntubatu S, Prawirohartono EP, Arguni E. Myocarditis prevalence in paediatric dengue infection: A prospective study in a tertiary hospital in Yogyakarta, Indonesia. J Trop Pediatr. 2019;65(6):603-8. doi: 10.1093/tropej/fmz020.
Cabrera-Rego JO, et al. Manifestaciones cardiovasculares en pacientes hospitalizados con dengue. Enferm Infecc Microbiol Clin. 2021;39(3):115-8.
Corré J, et al. Spontaneous coronary hematoma concomitant with myocarditis: the first report of double cardiac complication of dengue. ESC Heart Fail. 2023;10(2):1445-48.
Farrukh MBBS A, et al. Unveiling the dual threat: myocarditis in the spectrum of dengue fever. Curr Probl Cardiol. 2024;49(1). doi: 10.1016/j.cpcardiol.2023.100943.
Khan MB, et al. Visão geral da dengue: uma revisão sistêmica atualizada. J Infectar a saúde pública. Outubro de 2023; 16(10):1625-1642. DOI: 10.1016/j.jiph.2023.08.001. Epub 2023 3 de agosto. PMID: 37595484..
Kularatne SA, Dalugama C. Infecção por dengue: importância global, imunopatologia e manejo. Clin Med (Londres). Janeiro de 2022; 22(1):9-13. DOI: 10.7861/clinmed.2021-0791. PMID: 35078789; PMCID: PMC8813012.
Gupta S, Gupta M, Kashyap JR, Arora SK. Early cardiovascular involvement in dengue fever: A prospective study with two-dimensional speckle tracking echocardiography. Trop Doct. 2022;52(2):285-92. doi: 10.1177/00494755221076686.
Jadav N, et al. Unmasking the hidden threat of cardiac involvement in dengue fever: A critical longitudinal study. Cureus. 2023 Sep 25;15(9). doi: 10.7759/cureus.45961. PMID: 37900359; PMCID: PMC10600330.
Jatene IB, et al. Tratado de cardiologia SOCESP. [São Paulo]: Editora Manole; 2022. E-book. ISBN 9786555765182.
Kangussu LM, et al. Dengue virus infection induces inflammation and oxidative stress on the heart. Heart. 2022;108(5):388-96. doi: 10.1136/heartjnl-2020- 318912. Epub 2021 May 28. PMID: 34049953.
Mansanguan C, Hanboonkunupakarn B, Muangnoicharoen S, et al. Cardiac evaluation in adults with dengue virus infection by serial echocardiography. BMC Infect Dis. 2021;21(1):940. doi: 10.1186/s12879-021- 06639-x. PMID: 34507547; PMCID: PMC8431916.
Mokanpally S, et al. Myocarditis manifestations in dengue cases: A systematic review and meta-analysis. J Infect Public Health. 2023;16(11):1761-8. doi: 10.1016/j.jiph.2023.08.005.
Nerella S, Sarkar UK, Namdeo H. Electrocardiographic and echocardiographic findings in children with dengue infection. J Family Med Prim Care. 2022;11(6):2334-9. doi: 10.4103/jfmpc.jfmpc_1280_21. Epub 2022 Jun 30. PMID: 36119231; PMCID: PMC9480629.
Rahim A, et al. Cardiovascular sequelae of dengue fever: a systematic review. Expert Rev Cardiovasc Ther. 2022;20(6):465-79. doi: 10.1080/14779072.2022.2082945. Epub 2022 Jun 2. PMID: 35612830.
Sandeep M, et al. Myocarditis manifestations in dengue cases: A systematic review and meta-analysis. J Infect Public Health. 2023;16(11):1761-8.
Silva SJ , et al. Cardiac involvement in Dengue infection - a comprehensive review on pathophysiology, epidemiology, clinical manifestations, diagnosis and treatment.
Santos MFR, et al. Dengue: uma análise clínica correlacionada às comorbidades cardíacas e dados epidemiológicos da arbovirose no estado de São Paulo durante o período pandêmico da Covid-19 até 2023. Braz J Health Rev. 2024;7(1):3581-95.
Shah C, Vijayaraghavan G, Kartha CC. Spectrum of cardiac involvement in patients with dengue fever. Int J Cardiol. 2021; 324:180-5.
Sociedade Brasileira de Cardiologia. Nova Diretriz de Miocardites 2022. Arq Bras Cardiol. 2022;119(1):143-211. Available from: https://www.portal.cardiol.br/post/sbc-lan%C3%A7a-em-julho-nova- diretriz-de-miocardites. Accessed February 11, 2024.
Soneja M, Bhatt M, Farooqui FA, et al. Myocarditis in dengue: A prospective observational study. Open Forum Infect Dis. 2019;6(Suppl 2). doi: 10.1093/ofid/ofz360.2332.
Sud R, Agarwal N, Aishwarya V, et al. A case series of dengue myocarditis: A complication observed in dengue patients. Cureus. 2023 Nov 4;15(11). doi: 10.7759/cureus.48285. PMID: 38058326; PMCID: PMC10696278.
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Copyright (c) 2024 Rafael Melo Lopes, Yana Dantas Fernandes Veras, Janielly Zenette Alves Guedes Da Silva, João De Sena Bernardo, Marcos Paulo de Sena Rodrigues, Sean De Holanda Angelim Santos, Maria Eloisa De Castro Lima, Raimundo Dário Coelho Campelo, Orleâncio Gomes Ripardo de Azevedo, Raquel Gondim Moreira