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Abstract
Neuroplasticity occurs from human development until the end of senility and, despite the dependence on food, the regulation of the diet on neurons and nerve synapses is not restricted to the availability of nutrients. In turn, intermittent fasting, as a dietary strategy, represents not only a modern technique for weight loss, but also an important historical factor for the occurrence of persistent organic adaptations. Based on this interrelation, evidence was collected from databases that associated, positively or negatively, neuroplasticity with intermittent fasting in humans. From the review of the selected articles, the various ways in which intermittent fasting affects neuroplasticity, influencing energy metabolism, triggering signaling pathways, modulating components of the immune system and altering cellular components were identified. All of these changes create a favorable environment for the emergence and maintenance of neurons, as well as for the formation of new nerve synapses.
References
BRUSSEL, L. VAN; GERITS, A.; ARCKENS, L. Evidence for Cross-Modal Plasticity in Adult Mouse Visual Cortex Following Monocular Enucleation. Cerebral Cortex, 1 set. 2011. v. 21, n. 9, p. 2133–2146. Disponível em: <https://academic.oup.com/cercor/article-lookup/doi/10.1093/cercor/bhq286>.
CABO, R. DE; MATTSON, M. P. Effects of Intermittent Fasting on Health, Aging, and Disease. New England Journal of Medicine, 26 dez. 2019. v. 381, n. 26, p. 2541–2551. Disponível em: <http://www.nejm.org/doi/10.1056/NEJMra1905136>.
CHERIF, A. et al. Effects of Intermittent Fasting, Caloric Restriction, and Ramadan Intermittent Fasting on Cognitive Performance at Rest and During Exercise in Adults. Sports Medicine, 2016. v. 46, n. 1, p. 35–47.
KANDEL, E. R.; TAUC, L. Mechanism of Prolonged Heterosynaptic Facilitation. Nature, abr. 1964. v. 202, n. 4928, p. 145–147. Disponível em: <http://www.nature.com/articles/202145a0>.
KNUDSEN, E. I. Sensitive Periods in the Development of the Brain and Behavior. Journal of Cognitive Neuroscience, out. 2004. v. 16, n. 8, p. 1412–1425. Disponível em: <https://direct.mit.edu/jocn/article/16/8/1412-1425/3895>.
LANGILLE, J. J.; BROWN, R. E. The Synaptic Theory of Memory: A Historical Survey and Reconciliation of Recent Opposition. Frontiers in Systems Neuroscience, 26 out. 2018. v. 12. Disponível em: <https://www.frontiersin.org/article/10.3389/fnsys.2018.00052/full>.
MATTSON, M. P. et al. Intermittent metabolic switching, neuroplasticity and brain health. Nature Reviews Neuroscience, 11 fev. 2018. v. 19, n. 2, p. 81–94. Disponível em: <http://www.nature.com/articles/nrn.2017.156>.
______; ARUMUGAM, T. V. Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States. Cell Metabolism, jun. 2018. v. 27, n. 6, p. 1176–1199. Disponível em: <https://linkinghub.elsevier.com/retrieve/pii/S1550413118303188>.
RAEFSKY, S. M.; MATTSON, M. P. Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance. Free radical biology & medicine, 2017. v. 102, p. 203–216. Disponível em: <http://www.ncbi.nlm.nih.gov/pubmed/27908782>.
SANTOS-MONTEIRO, J. et al. Estimulação psicossocial e plasticidade cerebral em desnutridos. Revista Brasileira de Saúde Materno Infantil, abr. 2002. v. 2, n. 1, p. 15–22. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pi38292002000100003&lng=pt&tlng=pt>.
SIBILLE, K. T. et al. Increasing neuroplasticity to bolster chronic pain treatment: A role for intermittent fasting and glucose administration? Journal of Pain, 2016. v. 17, n. 3, p. 275–281. Disponível em: <http://dx.doi.org/10.1016/j.jpain.2015.11.002>.
VOSS, P. et al. Dynamic Brains and the Changing Rules of Neuroplasticity: Implications for Learning and Recovery. Frontiers in Psychology, 4 out. 2017. v. 8. Disponível em: <http://journal.frontiersin.org/article/10.3389/fpsyg.2017.01657/full>.