Keywords
COVID-19. SARS-CoV-2. Central nervous system. Neurological alterations. Neurophysiopathology.
How to Cite
Benevides Almeida , D. ., Chrystine Balestro Mota, S. ., Beatriz Aguiar Sanford, A. ., Conde de Queiroz, T. ., da Silva Mesquita, D. ., & Eduardo Ribeiro Honório Júnior, J. . (2021). CHARACTERISTICS OF THE CENTRAL NERVOUS SYSTEM ACCOMMODATION BY SARS-COVS-2 (COVID-19). Health and Society, 1(03). https://doi.org/10.51249/hes01.03.2021.355
Abstract
The new coronavirus, called SARS-Cov-2, discovered in December 2019 in Wuhan, China, is already responsible for more than 3 million deaths worldwide, according to the WHO. The virus is responsible for attacking the respiratory, digestive and nervous systems, invading the cells of these systems that have the angiotensin-converting enzyme receptor 2 (ACE-2). The disease is being continuously studied and new scientific findings are being discovered every day. One of the most relevant guidelines is the involvement of the central nervous system by the coronavirus. Several cases have reported neurological symptoms such as headache, anosmia, ageusia, dizziness, seizures and in more severe cases acute cerebrovascular disease, encephalopathies and Guillain-Barré syndrome. In this context, some hypotheses were raised as to how this neuroinvasion would occur and two routes are pointed out as the main ones: neuronal and hematogenic. Given this scenario, we carried out this work with the aim of better understanding the role of SARS-CoV-2 in the central nervous system and its neurotropism, through a narrative review of the literature. A search for scientific articles was carried out using SciELO, Scholar Google and SpringerLink, using the keywords COVID-19, SARS-CoV-2, central nervous system, neurological changes and neurophysiopathology. We seek only complete review articles published in the last year and a half, in Portuguese, English and Spanish. The exclusion criteria were incomplete articles, with more than one and a half years published. During the search, 48 articles were found, of which 24 fit the specific selection criteria.
References
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Costa, Andreia; Silva-Pinto, André (2020), “Neurological manifestations and COVID-19”, Acta Médica Portuguesa, 33, 12, 787-788. Versão eletrónica, consultada a 2.12.20, em https://actamedicaportuguesa.com/revista/index.php/amp/article/view/14504.
Costa, Rafael Everton Assunção Ribeiro da et al. (2020), “Complicações neurológicas em pacientes infectados por coronavírus”, Research, Society and Development, 9, 8, e242985687-e242985690. Versão eletrónica, consultada a 3.12.20, em https://rsdjournal.org/index.php/rsd/article/view/5687.
Felice, Fernanda Guarino de et al. (2020), “Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the central nervous system”, Trends in neurosciences, 43, 6, 355-357. Versão eletrónica, consultada a 9.12.20, em https://www.sciencedirect.com/science/article/abs/pii/S0166223620300916.
Iadecola, Constantino et al. (2020), “Effects of COVID-19 on the Nervous System”, Cell, 183, 16-28. Versão eletrónica, consultada a 7.4.21, em https://www.cell.com/cell/fulltext/S0092-8674(20)31070-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420310709%3Fshowall%3Dtrue.
Jarrahi, Abbas et al. (2020), “Neurological consequences of COVID-19: what have we learned and where do we go from here?”, Journal of Neuroinflammation, 17, 1, 1-12. Versão eletrónica, consultada a 12.2.21, em https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-020-01957-4.
Josephson, Andrew; Kamel, Hooman (2020), “Neurology and COVID-19”, Jama, 324, 12, 1139-1140. Versão eletrónica, consultada a 16.12.20, em https://jamanetwork.com/journals/jama/article-abstract/2770855.
Koralnik, Igor Jerome; Tyler, Kenneth (2020), “COVID‐19: a global threat to the nervous system”, Annals of neurology, 88, 1, 1-11. Versão eletrónica, consultada a 15.12.20, em https://onlinelibrary.wiley.com/doi/full/10.1002/ana.25807.
Leonardi, Matilde et al. (2020), “Neurological manifestations associated with COVID-19: a review and a call for action”, Journal of neurology, 267, 1573-1576. Versão eletrónica, consultada a 15.12.20, em https://link.springer.com/article/10.1007%2Fs00415-020-09896-z.
Meira, Isabella D.’Andrea et al. (2020), “Neurological implications of SARS-CoV-2 infection: review of literature”, Revista Brasileira de Neurologia, 56, 2, 10-19. Versão eletrónica, consultada a 15.12.20, em https://docs.bvsalud.org/biblioref/2020/07/1102905/revista-562-10-19.pdf.
Needham, Edward et al. (2020), “Neurological implications of COVID-19 infections”, Neurocritical Care, 32, 3, 667-671. Versão eletrónica, consultada a 1.3.21, em https://link.springer.com/article/10.1007%2Fs12028-020-00978-4.
Neta, Maria de Lourdes Guedes et al. (2020), “Aspectos Cognitivos e Neurológicos da Covid-19: Uma Análise a Partir da Tradução Livre de Quatro Estudos”, Revista Enfermagem e Saúde Coletiva, 5, 1, 17-23. Versão eletrónica, consultada a 2.3.21, em https://www.researchgate.net/profile/Sarah-Moretti/publication/342899145_Aspectos_Cognitivos_e_Neurologicos_da_Covid-19_Uma_Analise_a_Partir_da_Traducao_Livre_de_Quatro_Estudos/links/5f0c81ca299bf1074452f133/Aspectos-Cognitivos-e-Neurologicos-da-Covid-19-Uma-Analise-a-Partir-da-Traducao-Livre-de-Quatro-Estudos.pdf.
Nunes, Maria Jussara Medeiros et al. (2020), “Alterações Neurológicas Na Covid-19: Uma Revisão Sistemática”, Revista Neurociências, 28, 1-22. Versão eletrónica, consultada a 15.12.20, em https://periodicos.unifesp.br/index.php/neurociencias/article/view/10949.
Oliveira, Vinicius Faustino Lima de; Ferreira, Elane de Nazaré Magno (2020), “Complicações Neurológicas oriundas da infecção por SARS-CoV-2: uma revisão da literatura”, Revista Neurociências, 28, 1-14. Versão eletrónica, consultada a 15.12.20, em https://periodicos.unifesp.br/index.php/neurociencias/article/view/10789.
Román, Gustavo et al. (2020), “The neurology of COVID-19 revisited: A proposal from the Environmental Neurology Specialty Group of the World Federation of Neurology to implement international neurological registries”, Journal of the neurological sciences, 414, 116884-116896. Versão eletrónica, consultada a 15.12.20, em https://www.jns-journal.com/article/S0022-510X(20)30220-3/fulltext.
Silva, Bruno et al. (2020), “Manifestações Neurológicas em Doentes com Infeção por SARS-CoV-2”, Sinapse, 20, 2, 9-16. Versão eletrónica, consultada a 7.4.21, em http://www.sinapse.pt/section.php?id=60.
Silva, Marilia Rosa et al. (2020), “Complicações Neurológicas do SARS-CoV-2”, Brazilian Journal of Health Review, 3, 5, 14810-14829. Versão eletrónica, consultada a 7.4.21, em https://www.brazilianjournals.com/index.php/BJHR/article/view/18575/14963.
Souza Gomes, Andressa de et al. (2020), “Associação entre o COVID-19 e manifestações neurológicas”, Brazilian Journal of Development, 6, 11, 88950-88961. Versão eletrónica, consultada a 15.12.20, em https://www.brazilianjournals.com/index.php/BRJD/article/view/19996/16018.
Tsivgoulis, Georgios et al. (2020), “Neurological manifestations and implications of COVID-19 pandemic”, Therapeutic advances in neurological disorders, 13, 1-14. Versão eletrónica, consultada a 15.12.20, em https://journals.sagepub.com/oi/10.1177/1756286420932036.
Yavarpour-Bali, Hanie; Ghasemi-Kasman, Maryam (2020) “Update on neurological manifestations of COVID-19”, Life sciences, 118063-118071. Versão eletrónica, consultada a 16.12.20, em https://www.sciencedirect.com/science/article/abs/pii/S0024320520308146?via%3Dihub.
Zhou, Zhiqiang et al. (2020), “Understanding the neurotropic characteristics of SARS-CoV-2: from neurological manifestations of COVID-19 to potential neurotropic mechanisms”, Journal of neurology, 267, 2179-2184. Versão eletrónica, consultada a 15.12.20, em https://link.springer.com/article/10.1007%2Fs00415-020-09929-7
Ahmad, Imran; Rathore, Farooq Azam (2020), “Neurological manifestations and complications of COVID-19: A literature review”, Journal of Clinical Neuroscience, 77, 8-12. Versão eletrónica, consultada a 15.12.20, em https://www.jocn-journal.com/article/S0967-5868(20)31078-X/fulltext.
Al‐Sarraj, Safa et al. (2020) “Invited Review: The spectrum of neuropathology in COVID‐19”, Neuropathology and applied neurobiology, 47, 1, 3-16. Versão eletrónica, consultada a 16.12.20, em https://onlinelibrary.wiley.com/doi/full/10.1111/nan.12667.
Brito, Wallery Glleysianne Ferreira da; Silva, João Pedro Dantas Oliveira da (2020), “Impactos neuropatológicos do COVID-19”, Brazilian Journal of Health Review, 3, 3, 4227-4235. Versão eletrónica, consultada a 15.12.20, em https://www.brazilianjournals.com/index.php/BJHR/article/view/9702/8142.
Costa, Andreia; Silva-Pinto, André (2020), “Neurological manifestations and COVID-19”, Acta Médica Portuguesa, 33, 12, 787-788. Versão eletrónica, consultada a 2.12.20, em https://actamedicaportuguesa.com/revista/index.php/amp/article/view/14504.
Costa, Rafael Everton Assunção Ribeiro da et al. (2020), “Complicações neurológicas em pacientes infectados por coronavírus”, Research, Society and Development, 9, 8, e242985687-e242985690. Versão eletrónica, consultada a 3.12.20, em https://rsdjournal.org/index.php/rsd/article/view/5687.
Felice, Fernanda Guarino de et al. (2020), “Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the central nervous system”, Trends in neurosciences, 43, 6, 355-357. Versão eletrónica, consultada a 9.12.20, em https://www.sciencedirect.com/science/article/abs/pii/S0166223620300916.
Iadecola, Constantino et al. (2020), “Effects of COVID-19 on the Nervous System”, Cell, 183, 16-28. Versão eletrónica, consultada a 7.4.21, em https://www.cell.com/cell/fulltext/S0092-8674(20)31070-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420310709%3Fshowall%3Dtrue.
Jarrahi, Abbas et al. (2020), “Neurological consequences of COVID-19: what have we learned and where do we go from here?”, Journal of Neuroinflammation, 17, 1, 1-12. Versão eletrónica, consultada a 12.2.21, em https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-020-01957-4.
Josephson, Andrew; Kamel, Hooman (2020), “Neurology and COVID-19”, Jama, 324, 12, 1139-1140. Versão eletrónica, consultada a 16.12.20, em https://jamanetwork.com/journals/jama/article-abstract/2770855.
Koralnik, Igor Jerome; Tyler, Kenneth (2020), “COVID‐19: a global threat to the nervous system”, Annals of neurology, 88, 1, 1-11. Versão eletrónica, consultada a 15.12.20, em https://onlinelibrary.wiley.com/doi/full/10.1002/ana.25807.
Leonardi, Matilde et al. (2020), “Neurological manifestations associated with COVID-19: a review and a call for action”, Journal of neurology, 267, 1573-1576. Versão eletrónica, consultada a 15.12.20, em https://link.springer.com/article/10.1007%2Fs00415-020-09896-z.
Meira, Isabella D.’Andrea et al. (2020), “Neurological implications of SARS-CoV-2 infection: review of literature”, Revista Brasileira de Neurologia, 56, 2, 10-19. Versão eletrónica, consultada a 15.12.20, em https://docs.bvsalud.org/biblioref/2020/07/1102905/revista-562-10-19.pdf.
Needham, Edward et al. (2020), “Neurological implications of COVID-19 infections”, Neurocritical Care, 32, 3, 667-671. Versão eletrónica, consultada a 1.3.21, em https://link.springer.com/article/10.1007%2Fs12028-020-00978-4.
Neta, Maria de Lourdes Guedes et al. (2020), “Aspectos Cognitivos e Neurológicos da Covid-19: Uma Análise a Partir da Tradução Livre de Quatro Estudos”, Revista Enfermagem e Saúde Coletiva, 5, 1, 17-23. Versão eletrónica, consultada a 2.3.21, em https://www.researchgate.net/profile/Sarah-Moretti/publication/342899145_Aspectos_Cognitivos_e_Neurologicos_da_Covid-19_Uma_Analise_a_Partir_da_Traducao_Livre_de_Quatro_Estudos/links/5f0c81ca299bf1074452f133/Aspectos-Cognitivos-e-Neurologicos-da-Covid-19-Uma-Analise-a-Partir-da-Traducao-Livre-de-Quatro-Estudos.pdf.
Nunes, Maria Jussara Medeiros et al. (2020), “Alterações Neurológicas Na Covid-19: Uma Revisão Sistemática”, Revista Neurociências, 28, 1-22. Versão eletrónica, consultada a 15.12.20, em https://periodicos.unifesp.br/index.php/neurociencias/article/view/10949.
Oliveira, Vinicius Faustino Lima de; Ferreira, Elane de Nazaré Magno (2020), “Complicações Neurológicas oriundas da infecção por SARS-CoV-2: uma revisão da literatura”, Revista Neurociências, 28, 1-14. Versão eletrónica, consultada a 15.12.20, em https://periodicos.unifesp.br/index.php/neurociencias/article/view/10789.
Román, Gustavo et al. (2020), “The neurology of COVID-19 revisited: A proposal from the Environmental Neurology Specialty Group of the World Federation of Neurology to implement international neurological registries”, Journal of the neurological sciences, 414, 116884-116896. Versão eletrónica, consultada a 15.12.20, em https://www.jns-journal.com/article/S0022-510X(20)30220-3/fulltext.
Silva, Bruno et al. (2020), “Manifestações Neurológicas em Doentes com Infeção por SARS-CoV-2”, Sinapse, 20, 2, 9-16. Versão eletrónica, consultada a 7.4.21, em http://www.sinapse.pt/section.php?id=60.
Silva, Marilia Rosa et al. (2020), “Complicações Neurológicas do SARS-CoV-2”, Brazilian Journal of Health Review, 3, 5, 14810-14829. Versão eletrónica, consultada a 7.4.21, em https://www.brazilianjournals.com/index.php/BJHR/article/view/18575/14963.
Souza Gomes, Andressa de et al. (2020), “Associação entre o COVID-19 e manifestações neurológicas”, Brazilian Journal of Development, 6, 11, 88950-88961. Versão eletrónica, consultada a 15.12.20, em https://www.brazilianjournals.com/index.php/BRJD/article/view/19996/16018.
Tsivgoulis, Georgios et al. (2020), “Neurological manifestations and implications of COVID-19 pandemic”, Therapeutic advances in neurological disorders, 13, 1-14. Versão eletrónica, consultada a 15.12.20, em https://journals.sagepub.com/oi/10.1177/1756286420932036.
Yavarpour-Bali, Hanie; Ghasemi-Kasman, Maryam (2020) “Update on neurological manifestations of COVID-19”, Life sciences, 118063-118071. Versão eletrónica, consultada a 16.12.20, em https://www.sciencedirect.com/science/article/abs/pii/S0024320520308146?via%3Dihub.
Zhou, Zhiqiang et al. (2020), “Understanding the neurotropic characteristics of SARS-CoV-2: from neurological manifestations of COVID-19 to potential neurotropic mechanisms”, Journal of neurology, 267, 2179-2184. Versão eletrónica, consultada a 15.12.20, em https://link.springer.com/article/10.1007%2Fs00415-020-09929-7
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